Combined pregnancy: the Mount Sinai experience
Bello GV,
GAETANO V. BELLO,
G V Bello,
D Schonholz,
David H. Schonholz,
Schonholz D,
J Moshirpur,
Moshirpur J,
Dai-Yun Jeng,
D Y Jeng,
Jeng DY,
Richard L. Berkowitz,
Berkowitz RL,
R L Berkowitz
Case report
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AI-generated summary
by qwen3.7-flash, 2026-09-08
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This report describes nine cases of heterotopic pregnancy, highlighting their diverse clinical presentations in patients with endometriosis or infertility and advocating for early laparoscopy to ensure accurate diagnosis and prevent inadvertent termination of intrauterine gestations.
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AI-generated deep summary
by qwen3.7-flash, 2026-09-08
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This case series from The Mount Sinai Medical Center examines nine instances of heterotopic pregnancy, defined as the coexistence of intrauterine and extrauterine gestations. The authors highlight diverse clinical presentations, including cases arising after postabortal states, endometriosis treatment, and ovulation induction, while noting historical diagnostic challenges. Ultrasonography is discussed for its utility and limitations in detection, with recommendations for early laparoscopic intervention when clinical suspicion is high. A significant caveat involves the risk of inadvertently terminating a viable intrauterine pregnancy during curettage intended for ectopic management in infertility patients. Relevance to endometriosis: listed as one indication for GnRH antagonists, though the paper's main focus is uterine fibroids.
Abstract
Nine recent cases of coexisting intra- and extrauterine pregnancy at The Mount Sinai Medical Center are presented. The myriad of clinical presentations is exemplified in the postabortal, endometriosis, posttreatment; ovulation induction, and routine "rule-out ectopic" situations. A brief review of the literature follows detailing historical reports of diagnostic inaccuracy and delayed diagnosis. Several studies are cited supporting the difficulty of correctly diagnosing heterotopic pregnancy as well as factors which may predispose to it. The advantages and pitfalls of ultrasonography are mentioned as well as recommendations for early laparoscopic intervention when clinical history and ultrasound are suggestive. Caution is advised in those infertility patients who may undergo "routine" curettage at laparoscopy for ectopic pregnancy and thus, be at risk for inadvertent termination of an otherwise salvageable intrauterine pregnancy. This report further supports several other reviews in noting that the incidence of combined pregnancy may be much greater than formerly appreciated.
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Combined Pregnancy
The Mount Sinai Experience
- GAETANO V. BELLO
- DAVID SCHONHOLZ
- JASMIN MOSHIRPUR
- DAI-YUN JENG
- RICHARD L. BERKOWITZ
Nine recent cases of coexisting intra- and extrauterine pregnancy at The Mount Sinai Medical Center are presented. The myriad of clinical presentations is exemplified in the postabortal, endometriosis, posttreatment; ovulation induction, and routine “rule-out ectopic” situations. A brief review of the literature follows detailing historical reports of diagnostic inaccuracy and delayed diagnosis. Several studies are cited supporting the difficulty of correctly diagnosing heterotopic pregnancy as well as factors which may predispose to it. The advantages and pitfalls of ultrasonography are mentioned as well as recommendations for early laparoscopic intervention when clinical history and ultrasound are suggestive. Caution is advised in those infertility patients who may undergo “routine” curettage at laparoscopy for ectopic pregnancy and thus, be at risk for inadvertent termination of an otherwise salvageable intrauterine pregnancy. This report further supports several other reviews in noting that the incidence of combined pregnancy may be much greater than formerly appreciated.
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Condition tags
endometriosisinfertility
MeSH descriptors
Pregnancy
Pregnancy
Pregnancy, Ectopic
Adult
Adult
Female
Female
Humans
Humans
Pregnancy, Ectopic
Pregnancy, Ectopic
Pregnancy, Ectopic
Pregnancy, Ectopic
Pregnancy, Tubal
Pregnancy, Tubal
Pregnancy, Tubal
Pregnancy, Tubal
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- europepmc
- last seen: 2026-10-22T06:08:12.857683+00:00
- openalex
- last seen: 2026-06-04T00:00:01.174412+00:00
- pubmed
- last seen: 2026-10-08T21:41:21.390074+00:00
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