Effect of uterine horn ligation on bone mass: an experimental study in rats

H. Rico, Horatio Rico, Carmen de la Cuesta Benjumea, C. Cuesta, J. Cortés, C. Seco, M D Monteagudo, E. R. Hernández
European Journal of Obstetrics & Gynecology and Reproductive Biology · 2002 · vol. 102(1) , pp. 48–52 · doi:10.1016/s0301-2115(01)00570-x · PMID:12039089 · W2085124993
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This experimental study in rats investigated the effect of uterine horn ligation on bone mass.

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Abstract

OBJECTIVE: After tubal ligation, normal bone mass in the presence of gonadal deficit has been reported. These incongruent results motivated us to examine the topic. STUDY DESIGN: Bone mass was assessed by densitometry and ultrasonography 60 days after surgery on 100-day-old female Wistar rats. Fifteen Wistar rats with uterine horn ligation (TL) were compared with 15 unoperated, 15 with a sham uterine horn ligation (Sham-TL), and 15 ovariectomized (OVX), using ANOVA and a correlation test to determine the relations between results. RESULTS: Femoral and vertebral bone mass were significantly lower in the OVX y TL groups than in unoperated and controls groups (P<0.0001). CONCLUSIONS: Our study revealed significantly lower axial and peripheral bone mass in rats with uterine horn ligation.

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MeSH descriptors

Bone Density Uterus Animals Female Femur Femur Femur Ligation Linear Models Organ Size Ovariectomy Rats Rats, Wistar Ultrasonography Uterus

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