Expression and significance of ERβ and TrkB in endometriosis
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Abstract
OBJECTIVES: To study the potential pathogenesis of endometriosis (EMs) in an area of estrogen receptors (ERs) and tyrosine kinase receptor type B (TrkB) expressions in tissues from patients with EMs. STUDY DESIGN: The authors examined the expressions of ERα, ERβ, TrkB, brain-derived neurotrophic factor (BDNF), and SGPL1 in tissues with EMs, using real-time PCR, western blot, and immunohistochemistry. RESULTS: ERα and SGPL1 were mainly expressed in eutopic endometrium than that in ectopic endometrium of patients with ovarian endometriosis (p < 0.05), while ERβ, BDNF, and TrkB were adverse, mainly detected in ectopic endometrium of the same patients with EMs (p < 0.01 and p < 0.05 ) by real-time PCR and western blot. ERβ, ERα, TrkB, and SGPL1 proteins were mainly expressed in eutopic endometrium of proliferative phase with EMs than that in eutopic endometrium of secretory phase (p < 0.05 ). TrkB, BDNF, and SGPL1 were not found in endometrium of proliferative or secretory phase in control group. CONCLUSIONS: ERβ expressed in cytoplasm may mediate pathogenesis of EMs.
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Cited by (13)
- Elucidating the role of Brain-Derived Neurotrophic Factor (BDNF) and its receptor Tyrosine Receptor Kinase B (TrkB) in the development and symptoms of endometriosis 2024
- The Biological Characteristics of Eutopic and Ectopic EndometrialProgenitor Cells in Endometriosis 2023
- BDNF and TrKB expression levels in patients with endometriosis and their associations with dysmenorrhoea 2022
- Polymorphisms in the 3′UTR Region of ESR2 and CYP19A1 Genes in Women With Endometriosis 2020
- Polymorphisms in the 3<a:math xmlns:a="http://www.w3.org/1998/Math/MathML" id="M1"> <a:msup> <a:mrow/> <a:mrow> <a:mo>′</a:mo> </a:mrow> </a:msup> </a:math>UTR Region of ESR2 and CYP19A1 Genes and Its Influence on Allele-Specific Gene Expression in Endometriosis 2020
- Integrated Bioinformatics Analysis Reveals Function and Regulatory Network of miR‐200b‐3p in Endometriosis 2020
- The Genetic Background of Endometriosis: Can ESR2 and CYP19A1 Genes Be a Potential Risk Factor for Its Development? 2020
- Bioinformatics strategy for the screening of key genes to differentiate adenomyosis from endometriosis (Review) 2019
- Progesterone Receptor B (PGR-B) Is Partially Methylated in Eutopic Endometrium From Infertile Women With Endometriosis 2019
- Immunohistochemical predictors of recurrent ovarian endometriomas after laparoscopic surgery 2018
- Predictive factors of ovarian endometrioma recurrence after laparoscopic excision: risk factors and prevention 2018
- Role of Brain-Derived Neurotrophic Factor in Endometriosis Pain 2017
- Increased serum levels of mBDNF in women with minimal and mild endometriosis have no predictive power for the disease 2017
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- pubmed
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