IMMUNE-GENETICS МARKERS OF GENITAL ENDOMETRIOSIS

Н. С. Меньшикова, K. S. Kublinskiy, Т. А. Агаркова, I. Evtushenko, V. V. Novitskiy, В. Н. Ткачев, И. О. Наследникова
In: International Journal of Advanced Studies · 2012 · vol. 2(1) · doi:10.12731/2227-930x-2012-1-14 · W2133267252
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This study identified immune-genetic markers of genital endometriosis, finding that specific genotypes of the IL10 and IL12 genes are associated with either susceptibility or a protective effect against the condition.

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This study utilizes molecular genetic methods to identify specific immune-genetic markers associated with genital endometriosis. The authors found that susceptibility to the condition is positively linked to CC and CA genotypes in the IL10 promoter region C-592A, as well as the AA genotype of the IL12 A1188C polymorphism. Conversely, the paper identifies protective effects against endometriosis for the AA genotype of the IL10 C-592A variant and the CC genotype of the IL12 A1188C variant. This paper is centrally about endometriosis — specifically focusing on the identification of genetic polymorphisms in interleukin genes that influence disease susceptibility and protection.

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Abstract

Modern molecular genetic methods have helped to reveal immune-genetic markers of genital endometriosis. It was shown, that susceptibility to endometriosis is positively associated with the genotypes СС and СА the promoter region С-592A of the gene IL10 and with the genotype АА polymorphism A1188C of the gene IL12. It was proved that the immune-genetic factors with protective effect against endometriosis are the polymorphism С-592A genotype АА of the gene IL10 and the genotype СС from polymorphism A1188C of the gene IL12. DOI: http://dx.doi.org/10.12731/2227-930X-2012-1-14
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IMMUNE-GENETICS МARKERS OF GENITAL ENDOMETRIOSIS Аннотация Modern molecular genetic methods have helped to reveal immune-genetic markers of genital endometriosis. It was shown, that susceptibility to endometriosis is positively associated with the genotypes СС and СА the promoter region С-592A of the gene IL10 and with the genotype АА polymorphism A1188C of the gene IL12. It was proved that the immune-genetic factors with protective effect against endometriosis are the polymorphism С-592A genotype АА of the gene IL10 and the genotype СС from polymorphism A1188C of the gene IL12. Ключевые слова Полный текст: >PDF (English)Литература Adamyan L.V., Kulakov V.I., Andreeva E.N. Endometriozy [Endometriosis]. M.: Medicine, 2006. 416 p. Ailamazyan E.K., Potin V.V., Tarasova M.A. and others. Ginekologiya ot pubertata do postmenopauzy [Gynecology from puberty to after-menopause]. M.: MEDpress-inform, 2007. P.284-302. Damirov M.M. Genital'nyy endometrioz – bolezn' aktivnykh i delovykh zhenshchin [Genital endometriosis – disease of active and business women]. Moscow, Binom-Press, 2010. 192 p. Ischenko A.I., Kudrina E.A. Endometrioz: diagnostika i lechenie [Endometriosis: diagnostic and therapy]. M.: MIA, 2008. 176 p. Kozlov V.A., Sennikov S.V. Sistema tsitokinov: Teoreticheskie i klinicheskie aspekty [Cytokine system: Theoretical and clinical aspects]. Novosibirsk: Science, 2004. 324 p. Simbirtsev A.C., Gromova A.Y. Immunologiya [Immunology], no. 1 (2005): 67. Allaire C. Endometriosis and infertility: a review // J. Reprod. Med. 2006. V.51.№3. Р.164-168. Harada T., Iwabe T., Terakawa N. Role of cytokines in endometriosis // Fertil. Steril. 2001. V. 76. №1. Р. 1-10. Iwabe T., Harada T., Terakawa N. Role of cytokines in endometriosis-associated infertility // Gynec. Obstet. Invest. 2002. V. 53. №1. Р. 19-25. Koninckx P.R., Kennedy S.H., Barlow D.H. Pathogenesis of endometriosis: the role of peritoneal fluid // Gynecol. Obstet. Investing. 1999. Vol. 47. N1. P. 23-33. Ссылки - На текущий момент ссылки отсутствуют. (c) 2016 International Journal of Advanced Studies Контент доступен под лицензией Creative Commons Attribution-NonCommercial-NoDerivs 4.0. ISSN 2328-1391 (print), ISSN 2227-930X (online)

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endometriosis

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