Differential inhibition of Scutellaria barbata D. Don (Lamiaceae) on HCG-promoted proliferation of cultured uterine leiomyomal and myometrial smooth muscle cells

Tae-Kyun Lee, Tae‐Kyun Lee, Dong-Il Kim, Dong‐Il Kim, Young‐Lim Song, Young-Lim Song, Young-Choon Lee, Young‐Choon Lee, Hyung-Min Kim, Hyung‐Min Kim, Cheorl‐Ho Kim, Cheorl-Ho Kim
Immunopharmacology and immunotoxicology · 2004 · vol. 26(3) , pp. 329–342 · doi:10.1081/iph-200026841 · PMID:15518168 · W2101050072
Lab / animal OA: closed CC0 ⤵ 2 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

This study investigated the effects of *Scutellaria barbata* on human chorionic gonadotrophin-stimulated proliferation and cell cycle protein expression in uterine leiomyomal and myometrial smooth muscle cells.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Scutellaria barbata D. Don (Lamiaceae)(SB) is a perennial herb which is natively distributed throughout Korea and southern China. This herb is known in traditional Chinese Medicine as Ban-Zhi-Lian and traditional Korean medicine as Banjiryun, respectively. SB has been used as an anti-inflammatory and antitumor agent. We aimed to determine the expressin of cell cycle-related signal molecules for growth inhibition after HCG treatment by the herb SB in two different human myometrial smooth muscle cells (SMCs) and leiomyomal SMCs. Water-soluble ingredients of SB, myometrial SMCs and the leiomyomal cell lines were used in vitro. Uterine myomas often enlarge rapidly during pregnancy, implying that human chorionic gonadotrophin (HCG) may influences cell proliferation in uterine leiomyomata. We investigated the effects of SB on the cell proliferation and the expression of cell cycle-related proteins in these cells. Although HCG/LH receptor was present in both cultured myometrial and leiomyomal cells, as assayed by reverse transcription polymerase chain reaction analysis, treatment with HCG significantly increased cell proliferation in both myometrial and leiomyomal cells. However, SB reduced the proliferative effect of HCG in leiomyoma and myometrial cells, respectively. In HCG-treated leiomyomal cells, the expression of proliferating cell nuclear antigen, cyclin E and cdc2 was significantly reduced by SB treatment. These results suggest that SB reduced the HCG-promoted proliferation of myometrial and leiomyomal cells.

My notes (saved in your browser only)

MeSH descriptors

Cell Cycle Proteins Chorionic Gonadotropin Drugs, Chinese Herbal Leiomyoma Myocytes, Smooth Muscle Myometrium Scutellaria Uterine Neoplasms Actins Actins Actins Adult CDC2-CDC28 Kinases CDC2-CDC28 Kinases CDC2-CDC28 Kinases CDC2 Protein Kinase CDC2 Protein Kinase CDC2 Protein Kinase Cell Cycle Proteins Cell Cycle Proteins

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (3)

Cited by (2)

References (42)

Cited by (2)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:02:47.667321+00:00
License: CC0 · commercial use OK