Vascular Endothelial Growth Factor Serum Levels in Women with Advanced Endometriosis

A Malutan, Andrei Mihai Măluţan, T Drugan, C Georgescu, R Ciortea, C Bucuri, A Bobric, M P Rada, D Mihu
Acta endocrinologica (Bucharest, Romania : 2005) · 2016 · vol. 12(1) , pp. 7–13 · doi:10.4183/aeb.2016.7 · PMID:31258793 · W2499235944
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This study found significantly lower serum levels of vascular endothelial growth factor (VEGF) in women with endometriosis compared to healthy controls.

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This study evaluated serum concentrations of multiple growth factors—VEGF, G-CSF, GM-CSF, b-FGF, EGF, and HGF—in 157 women with diagnosed endometriosis versus healthy controls, using Human Multiplex Cytokine Panels. VEGF levels were significantly lower in the endometriosis group than in controls, while GM-CSF, b-FGF, EGF, and HGF did not differ significantly; G-CSF also had a very low detection rate. The paper’s main caveat is that it relies on serum measurements and reports limited sensitivity for some factors (notably G-CSF), which may constrain interpretation. This paper is centrally about endometriosis — it measures circulating VEGF and reports its association with advanced endometriosis in women.

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Abstract

CONTEXT: Endometriosis is a common gynecological disease, characterized by ectopic deposits of endometrial tissue outside of the uterine cavity, and it is associated with pelvic pain and infertility, with an important impact on the quality of life. At this point there is a controversy regarding the etiology and pathophysiology of endometriosis and it seems that pro-angiogenic growth factors might be involved, but their role is not completely understood. OBJECTIVE: To evaluate the serum concentration of the main growth factors in patients with diagnosed endometriosis compared to healthy controls. SUBJECTS AND METHODS: A total of 157 women were divided into two study groups (Group I - endometriosis; Group 2 - healthy women). Serum levels of VEGF, G-CSF, GM-CSF, b-FGF, EGF, and HGF were measured with Human Multiplex Cytokine Panels. RESULTS: VEGF serum levels were significantly lower in women with endometriosis compared to controls (1.924±0.145 compared to 1.806±0.078 pg/mL, p<0.001). Serum levels of GM-CSF, b-FGF, EGF, and HGF respectively did not differ significantly between patients with endometriosis and healthy controls. G-CSF had a very low detection rate. CONCLUSIONS: The present study showed that VEGF serum levels are significantly lower in endometriosis patients compared to healthy controls, indicating a possible role in endometriosis pathogenesis.
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- Login - Register - Home/Current Issue - About the journal - Editorial board - Online submission - Instructions for authors - Subscriptions - Foundation Acta Endocrinologica - Archive - Contact Romanian Academy The Publishing House of the Romanian Academy ACTA ENDOCRINOLOGICA (BUC) The International Journal of Romanian Society of Endocrinology / Registered in 1938in Web of Science Master Journal List Acta Endocrinologica(Bucharest) is live in PubMed Central Journal Impact Factor - click here. This Article Services Google Scholar PubMed Acta Endocrinologica (Buc) Malutan A, Drugan T, Georgescu C, Ciortea R, Bucuri C, Bobric A, Rada MP, Mihu D Vascular Endothelial Growth Factor Serum Levels in Women with Advanced Endometriosis Acta Endo (Buc) 2016, 12 (1): 7-13doi: 10.4183/aeb.2016.7 Context. Endometriosis is a common gynecological disease, characterized by ectopic deposits of endometrial tissue outside of the uterine cavity, and it is associated with pelvic pain and infertility, with an important impact on the quality of life. At this point there is a controversy regarding the etiology and pathophysiology of endometriosis and it seems that pro-angiogenic growth factors might be involved, but their role is not completely understood. Objective. To evaluate the serum concentration of the main growth factors in patients with diagnosed endometriosis compared to healthy controls. S ubjects and Methods. A total of 157 women were divided into two study groups (Group I – endometriosis; Group 2 – healthy women). Serum levels of VEGF, G-CSF, GM-CSF, b-FGF, EGF, and HGF were measured with Human Multiplex Cytokine Panels. Results. VEGF serum levels were significantly lower in women with endometriosis compared to controls (1.924±0.145 compared to 1.806±0.078 pg/mL, p<0.001). Serum levels of GM-CSF, b-FGF, EGF, and HGF respectively did not differ significantly between patients with endometriosis and healthy controls. G-CSF had a very low detection rate. Conclusions. The present study showed that VEGF serum levels are significantly lower in endometriosis patients compared to healthy controls, indicating a possible role in endometriosis pathogenesis. Keywords: endometriosis, growth factors, immunology, inflammation. Correspondence: Tudor Drugan MD,“Iuliu Hatieganu” University of Medicine and Pharmacy, Department of Medical Informatics and Biostatistics, 6 Victor Babes, Cluj-Napoca, Cluj, 400012, Romania, E-mail: [email protected]

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endometriosisinfertility

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