Effect of Medical Assistance in the Treatment of Endometriosis After Surgery

Xueyin Wang, Yan Yan
2014 · vol. 10(1) , pp. 60–62 · doi:10.3877/cma.j.issn.1673-5250.2014.01.014 · W3031550833
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This study compared gestrinone, leuprorelin acetate microspheres, and leuprorelin acetate microspheres with an intrauterine device for postsurgical endometriosis treatment, finding similar efficacy and recurrence rates but differing side effect profiles.

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This study evaluated postoperative medical management for 80 patients with endometriosis who underwent laparotomy or laparoscopy, comparing gestrinone, leuprorelin acetate microspheres, and a combination of leuprorelin followed by levonorgestrel intrauterine system placement. The researchers found no significant differences in treatment efficacy or recurrence rates among the three groups, although adverse effect profiles varied, with gestrinone associated with higher transaminase levels and leuprorelin linked to more frequent hot flashes. The authors concluded that while overall outcomes were similar, the combined hormonal approach offered advantages regarding liver function preservation and symptom management for long-term therapy. This paper is centrally about endometriosis — specifically assessing adjunctive pharmacological interventions to prevent recurrence after surgical excision.

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Abstract

Objective To observe the curative effect, untoward effect and relapse rate after drug withdrawal in the patients with endometriosis who accepted the medical assistance of gestrinone, leuprorelin acetate microspheres, and placement of left acetylene progesterone intrauterine birth control system after three months' leuprorelin acetate microspheres therapy with laparotomy or laparoscopic surgery. Methods A total of 80 cases with endometriosis from March 2010 to June 2013 in Avic 363 hospital that went under the surgery were divided into (according to the patient's wishes) gestrinone group (n =28) , leuprorelin acetate microspheres group (n =32) and leuprorelin acetate microspheres with left acetylene progesterone intrauterine birth control system group (n =20) . The curative effect, untoward effect and relapse rate were compared among 3 groups. The study protocol was approved by the Ethical Review Board of Investigation in Human Beings of Avic 363 Hospital. Informed consent was obtained from each participating patient. Results There had no significant differences among 3 groups in the curative effect and relapse rate (P>0.05) meanwhile also had no significant differences in the untoward effect which performed as weight gain (P>0.05) . Transaminase lifted higher in gestrinone group and fever occurred more in leuprorelin acetate microspheres group than that in other 2 groups and had significant differences (P<0.01) . Conclusions Endometriosis after surgery and treated with gestrinone, leuprorelin acetate microspheres and leuprorelin acetate microspheres 3 months then with left acetylene progesterone intrauterine birth control system have similar curative effect. Placement of left acetylene progesterone intrauterine birth control system after three months' treatment with leuprorelin acetate microspherehas has small effect on liver function and can reduce hot flashes and can be a long-term treatment for endometriosis and reduce the recurrence Key words: Endometriosis; Surgery; Drug therapy
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Objective

To observe the curative effect, untoward effect and relapse rate after drug withdrawal in the patients with endometriosis who accepted the medical assistance of gestrinone, leuprorelin acetate microspheres, and placement of left acetylene progesterone intrauterine birth control system after three months' leuprorelin acetate microspheres therapy with laparotomy or laparoscopic surgery.

Methods

A total of 80 cases with endometriosis from March 2010 to June 2013 in Avic 363 hospital that went under the surgery were divided into (according to the patient's wishes) gestrinone group (n =28) , leuprorelin acetate microspheres group (n =32) and leuprorelin acetate microspheres with left acetylene progesterone intrauterine birth control system group (n =20) . The curative effect, untoward effect and relapse rate were compared among 3 groups. The study protocol was approved by the Ethical Review Board of Investigation in Human Beings of Avic 363 Hospital. Informed consent was obtained from each participating patient.

Results

There had no significant differences among 3 groups in the curative effect and relapse rate (P>0.05) meanwhile also had no significant differences in the untoward effect which performed as weight gain (P>0.05) . Transaminase lifted higher in gestrinone group and fever occurred more in leuprorelin acetate microspheres group than that in other 2 groups and had significant differences (P<0.01) .

Conclusions

Endometriosis after surgery and treated with gestrinone, leuprorelin acetate microspheres and leuprorelin acetate microspheres 3 months then with left acetylene progesterone intrauterine birth control system have similar curative effect. Placement of left acetylene progesterone intrauterine birth control system after three months' treatment with leuprorelin acetate microspherehas has small effect on liver function and can reduce hot flashes and can be a long-term treatment for endometriosis and reduce the recurrence | [1] | 郎景和．子宫内膜异位症研究的任务与展望之二[J]．中华妇产科杂志，2006，41(10):649-695． | | [2] | 谢幸，苟文丽，主编．妇产科学．8版[M]．北京：人民卫生出版社，2013:268-274． | | [3] | 曹泽毅．中华妇产科学[M]．北京：人民卫生出版社，2010:376-384． | | [4] | 曹泽毅．中华妇产科学[M]．北京：人民卫生出版社，1999:1299-1331． | | [5] | 花怀珍．腹腔镜联合药物治疗子宫内膜异位症的疗效观察[J]．中国临床保健杂志，2009，(4):380-381． | | [6] | 马永萍，李晓荣，陈冰．腹腔镜术后置曼月乐治疗子宫内膜异位症 [J]．西部医学，2009，(1):32-33． | | [7] | 孔彩霞，曹佩霞，金伟蓉．腹腔镜手术联合药物治疗子宫内膜异位症的临床疗效评价[J/CD]．中化妇幼临床医学杂志(电子版)，2013，9(5):642-645． | | [1] | 孙佳丽, 金琳, 沈崔琴, 陈晴晴, 林艳萍, 李朝军, 徐栋. 机器人辅助超声引导下经皮穿刺的体外实验研究[J/OL]. 中华医学超声杂志（电子版）, 2024, 21(09): 884-889. | | [2] | 李刘庆, 陈小翔, 吕成余. 全腹腔镜与腹腔镜辅助远端胃癌根治术治疗进展期胃癌的近中期随访比较[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 23-26. | | [3] | 刘世君, 马杰, 师鲁静. 胃癌完整系膜切除术+标准D2根治术治疗进展期胃癌的近中期随访研究[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 27-30. | | [4] | 李华志, 曹广, 刘殿刚, 张雅静. 不同入路下行肝切除术治疗原发性肝细胞癌的临床对比[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 52-55. | | [5] | 常小伟, 蔡瑜, 赵志勇, 张伟. 高强度聚焦超声消融术联合肝动脉化疗栓塞术治疗原发性肝细胞癌的效果及安全性分析[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 56-59. | | [6] | 韩戟, 杨力, 陈玉. 腹部形态CT参数与完全腹腔镜全胃切除术术中失血量的关系研究[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 88-91. | | [7] | 王露, 周丽君. 全腹腔镜下远端胃大部切除不同吻合方式对胃癌患者胃功能恢复、并发症发生率的影响[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 92-95. | | [8] | 孙一娇, 包润发, 董平, 束翌俊. PBL结合手术视频剪辑教学在普通外科专科医师规范化培训中的应用与思考[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 96-99. | | [9] | 陈浩, 王萌. 胃印戒细胞癌的临床病理特征及治疗选择的研究进展[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 108-111. | | [10] | 孙莲, 马红萍, 吴文英. 局部进展期甲状腺癌患者外科处理[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 112-114. | | [11] | 康婵娟, 张海涛, 翟静洁. 胰管支架置入术治疗急性胆源性胰腺炎的效果及对患者肝功能、炎症因子水平的影响[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 667-670. | | [12] | 付成旺, 杨大刚, 王榕, 李福堂. 营养与炎症指标在可切除胰腺癌中的研究进展[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 704-708. | | [13] | 刘柏隆. 女性压力性尿失禁阶梯治疗之手术治疗方案选择[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2025, 19(01): 126-126. | | [14] | 刘柏隆, 周祥福. 女性尿失禁吊带手术并发症处理的经验分享[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2025, 19(01): 127-127. | | [15] | 张耕毓, 唐冲, 张昆, 张辉, 张清华, 刘家帮. 股骨头坏死髓芯减压术的文献计量学分析及单中心病例报道[J/OL]. 中华临床医师杂志(电子版), 2024, 18(08): 771-780. | | 阅读次数 | ||||| | 全文 | | |||| | 摘要 | | |||| 版权所有 中华医学会 中华医学电子音像出版社有限责任公司 京ICP备14006079号-1 网络出版服务许可证：(署)网出证(京)字第075号 AI 小 编 AI小编

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