What evidence describes clear cell adenocarcinoma of the omentum or other extra-ovarian sites arising after bladder urothelial/transitional cell carcinoma or endometriosis, and what pathological evidence supports each proposed origin?

This review examines the pathological evidence linking clear cell adenocarcinoma at extra-ovarian sites, such as the omentum, to prior bladder urothelial carcinoma or endometriosis. The analysis highlights that while limited indirect evidence and case reports suggest an endometrial transformation origin from endometriosis, data connecting bladder cancer to these tumors remain sparse. The authors note a significant lack of comprehensive studies for the urothelial pathway compared to the established, albeit indirect, links with endometriosis. This paper is centrally about endometriosis — specifically its potential role as a precursor for extra-ovarian clear cell adenocarcinoma, contrasting it with less understood origins like bladder carcinoma.

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