Allelic Polymorphism OF GENES OF FACTORS OF ANGIOGENESES in case of Genital Endometriosis

K. S. Kublinskiy, И. Д. Евтушенко, V. V. Novitskiy, Ольга Ивановна Уразова, Yuliya Vladimirovna Kolobovnikova, Anna Kovaleva
In: V mire nauchnykh otkrytiy · 2016 · vol. 0(1) , pp. 24 · doi:10.12731/wsd-2016-1-24-35 · W2309053499
Observational OA: gold CC0 ⤵ 7 in-corpus citations
🔓 Open OA copy Full text JSON View on OpenAlex View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-07-17 ⓘ

Specific alleles and genotypes of VEGF, KDR, and Ang2 genes are associated with an increased predisposition to genital endometriosis in women.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by qwen3.7-flash, 2026-10-11 · read from full text ⓘ

This study investigated the association between allelic polymorphisms in angiogenesis-related genes and genital endometriosis using molecular genetic methods. The researchers identified that specific genotypes, including GC and CC for VEGF G-405C, GA and AA for VEGF G-1154A, TC and CC for KDR T-604C, and CA and GA for Ang2 G-735A, predispose women to developing the condition. These findings highlight the role of genetic variations in vascular endothelial growth factor and its receptors in the pathogenesis of endometriosis. This paper is centrally about endometriosis — specifically examining the genetic basis of angiogenesis factors associated with genital endometriosis.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

With the using modern molecular-genetic methods for the study it was shown that the allele C and genotypes GC and CC of the polymorphic variant G-405C of VEGF gene, allele A and genotypes GA and AA of the polymorphic region G-1154A of VEGF gene, allele C and genotypes ТС and СС of polymorphism T-604C of KDR gene as well as allele A and genotypes СА and GА of polymorphism G-735A of Ang2 gene predisposes to the development of genital endometriosis in women.
Full text 1,680 characters · extracted from oa-html · click to expand
АЛЛЕЛЬНЫЙ ПОЛИМОРФИЗМ ГЕНОВ ФАКТОРОВ АНГИОГЕНЕЗА ПРИ ГЕНИТАЛЬНОМ ЭНДОМЕТРИОЗЕ Аннотация С привлечением современных молекулярно-генетических методов исследования показано, что к развитию генитального эндометриоза у женщин предрасполагает носительство аллеля С и генотипов GC и CC полиморфного варианта G-405C гена VEGF, аллеля А и генотипов GA и АА полиморфного участка G-1154A гена VEGF, аллеля С и генотипов ТС и СС полиморфизма T-604C гена KDR, а также аллеля А и генотипов СА и GА полиморфизма G-735A гена Ang2. Ключевые слова Полный текст: >PDFЛитература Адамян Л.В., Кулаков В.И., Андреева Е.Н. Эндометриозы: Руководство для врачей. М.: Медицина, 2006. 416 с. Волкова Л.В., Аляутдина О.С. Клинико-диагностическое значение сосудисто-эндотелиального фактора роста при неудачных попытках ЭКО // Акушерство и гинекология. 2011. № 4. С. 126-129. Дамиров М.М. Современная тактика ведения больных с аденомиозом: практическое руководство. М.: Издательство БИНОМ; 2015. 112 с. Кузнецова И.В. Роль ангиогенеза в патогенезе эндометриоза // Акушерство и гинекология. 2011. № 5. С. 16-22. Чехонин В.П., Шеин С.А., Корчагина А.А. , Гурина О.И. Роль VEGF в развитии неопластического ангиогенеза // Вестник РАМН. 2012. № 2. С. 23-34 Iwabe T., Harada T., Terakawa N. Role of cytokines in endometriosis-associated infertility // Gynec. Obstet. Invest. 2002. Vol. 53, №1. P. 19-25. Nisolle M., Alvarez M.L., Colombo M., Foidart J.M. Pathogenesis of endometriosis. Gynecol. Obstet. Fertil., 2007, no. 35 (9), pp. 898-903. DOI: https://doi.org/10.12731/wsd-2016-1-24-35 Ссылки - На текущий момент ссылки отсутствуют. (c) 2016 В мире научных открытий ISSN 2658-6649 (print) ISSN 2658-6657 (online)

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-html ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

Cited by (6)

Source provenance

openalex
last seen: 2026-06-04T00:00:01.174412+00:00
License: CC0 · commercial use OK