Microbial Mysteries—Exploring the Microbiome\'s Impact on Endometriosis: A Review

Srinidhi Rai
In: Journal of South Asian Federation of Obstetrics and Gynaecology · 2025 · vol. 16(S3) , pp. S263–S267 · doi:10.5005/jp-journals-10006-2556 · W4408077433
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This review explores the current understanding of how alterations in the gut microbiota, including its role in immune responses and hormone metabolism, may contribute to the development and progression of endometriosis.

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Abstract

Tissue similar to endometrium found external to the uterus is a hallmark of the complex disorder called endometriosis (EM), which frequently results in infertility and severe pelvic pain.Current research has concentrated more on the microbiome's function-a varied community of bacteria that inhabit the human body-in influencing the advancement and course of this disease, even if its etiology is still not fully understood.This review explores current knowledge and emerging insights into the interplay between the microbiome and endometriosis.The gut microbiota's alterations may contribute to dysregulated immune responses and chronic inflammation, both of which are implicated in developing EM.Furthermore, the microbiome's involvement in hormone metabolism, particularly estrogen, suggests potential mechanisms through which it could influence disease progression.Comprehending the microbiome's function in endometriosis carries great potential for enhancing treatment and diagnostic methods, changing the way EM is managed, and possibly even improving patient outcomes.Sustained multidisciplinary investigations are crucial for deciphering the microbiological enigmas associated with this puzzling illness.

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Condition tags

endometriosisinfertility

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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