Benign Multicystic Peritoneal Mesothelioma Mimicking Acute Appendicitis: A Case Report

Dra. Ethel Cassandra Ramírez Ortiz, Jorge Andrés Myers Esmenjaud, Salvador Medina González
2026 · doi:10.5281/zenodo.19144042 · W7139983315
Case report OA: green CC0
🔓 Open OA copy Full text JSON View on OpenAlex View at publisher
⚙ AI-generated summary by qwen3.7-flash, 2026-08-26 ⓘ

A 34-year-old male presented with acute appendicitis symptoms, leading to the diagnosis of benign multicystic peritoneal mesothelioma via laparoscopy and histopathology, highlighting its association with endometriosis despite occurring in a man.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by qwen3.7-flash, 2026-08-26 · read from full text ⓘ

This case report describes a 34-year-old male presenting with acute right lower quadrant pain initially suspected to be appendicitis. Diagnostic laparoscopy revealed benign multicystic peritoneal mesothelioma, a rare tumor characterized by multiple thin-walled cysts on peritoneal surfaces, which was confirmed via histopathology after surgical resection. The authors note that while the condition is more common in women and often associated with prior abdominal surgery or endometriosis, this presentation in a male patient without those specific risk factors is uncommon. Relevance to endometriosis: listed as one of the conditions associated with the development of benign multicystic peritoneal mesothelioma, though the paper's main focus is a rare male case mimicking appendicitis.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Background: Benign multicystic peritoneal mesothelioma is a rare tumor derived from mesothelial cells characterized by multiple thin-walled cysts attached to the peritoneal surfaces. It occurs more frequently in women and has been associated with previous abdominal surgery, endometriosis, or pelvic inflammatory disease. Despite its benign nature, it has a high recurrence rate after surgical treatment. Case presentation: We report the case of a 34-year-old male with a history of bilateral varicocelectomy and bilateral inguinal hernioplasty who presented to the emergency department with acute onset right lower quadrant abdominal pain suggestive of acute appendicitis. Laboratory tests showed elevated C-reactive protein levels. Abdominal computed tomography revealed multiple well-defined cystic lesions in the right lower abdomen and pelvis. Diagnostic laparoscopy was performed due to suspicion of a periappendiceal abscess, revealing a 6 × 4 × 2 cm multicystic tumor attached to the mesentery and right colon, along with multiple grape-like cystic lesions throughout the abdominal cavity. Local tumor resection, removal of most cystic lesions, and appendectomy were performed. Histopathological examination confirmed the diagnosis of benign multicystic peritoneal mesothelioma. Conclusion: This case highlights an uncommon presentation of benign multicystic peritoneal mesothelioma in a male patient mimicking acute appendicitis. Laparoscopy plays an important role in both diagnosis and treatment, allowing complete surgical resection. Long-term follow-up is recommended due to the risk of recurrence.
Full text 2,116 characters · extracted from oa-doi-fallback · 2 sections · click to expand

Background

Benign multicystic peritoneal mesothelioma is a rare tumor derived from mesothelial cells characterized by multiple thin-walled cysts attached to the peritoneal surfaces. It occurs more frequently in women and has been associated with previous abdominal surgery, endometriosis, or pelvic inflammatory disease. Despite its benign nature, it has a high recurrence rate after surgical treatment. Case presentation: We report the case of a 34-year-old male with a history of bilateral varicocelectomy and bilateral inguinal hernioplasty who presented to the emergency department with acute onset right lower quadrant abdominal pain suggestive of acute appendicitis. Laboratory tests showed elevated C-reactive protein levels. Abdominal computed tomography revealed multiple well-defined cystic lesions in the right lower abdomen and pelvis. Diagnostic laparoscopy was performed due to suspicion of a periappendiceal abscess, revealing a 6 × 4 × 2 cm multicystic tumor attached to the mesentery and right colon, along with multiple grape-like cystic lesions throughout the abdominal cavity. Local tumor resection, removal of most cystic lesions, and appendectomy were performed. Histopathological examination confirmed the diagnosis of benign multicystic peritoneal mesothelioma.

Conclusion

This case highlights an uncommon presentation of benign multicystic peritoneal mesothelioma in a male patient mimicking acute appendicitis. Laparoscopy plays an important role in both diagnosis and treatment, allowing complete surgical resection. Long-term follow-up is recommended due to the risk of recurrence. Files 2736-Article Text-7214-1-10-20260320.pdf Files (276.8 kB) | Name | Size | Download all | |---|---|---| | md5:96f8e12c15695ff1dafff03917646868 | 276.8 kB | Preview Download |

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosis

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. This is a recent paper (2026) — citers typically take a year or two to land, and the OpenAlex reference graph may still be filling in.

Source provenance

openalex
last seen: 2026-05-13T19:05:42.629771+00:00
License: CC0 · commercial use OK