Gonadotrophin receptor hormone analogues in combination with add-back therapy: an update

James Samuel McLaren, James S. McLaren, Edward Morris, Janice Rymer
Menopause international · 2012 · vol. 18(2) , pp. 68–72 · doi:10.1258/mi.2012.012008 · W2008686181
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Abstract

Gonadotrophin receptor hormone analogues (GnRHa) have been used in a range of sex hormone-dependent disorders. In the management of premenstrual syndrome, they can completely abolish symptoms. The success of GnRHa in the treatment of endometriosis and adjuvant therapy in the management of fibroids is proven. This efficacy does not come without a cost and the side-effects of the hypo-estrogenic state have limited their application. The use of add-back therapy to counter these effects has enabled wider application, longer durations of treatment and an increase in compliance. This review article is an update on the evidence supporting gonadotrophin receptor hormone analogues in combination with add-back therapy.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Premenstrual Syndrome Bone Density Bone Density Bone Density Conservation Agents Bone Density Conservation Agents Calcitonin Calcitonin Diphosphonates Diphosphonates Endometriosis Endometriosis Estrogen Antagonists Estrogen Antagonists Estrogen Receptor Modulators Estrogen Receptor Modulators Female Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone

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License: CC0 · commercial use OK