15-Epi-lipoxin A(4) inhibits the progression of endometriosis in a murine model

Qiong-Hua Chen, Chen QH, Qionghua Chen, Zhou WD, Wei-Dong Zhou, Weidong Zhou, Pu DM, Demin Pu, De-Min Pu, Qiansheng Huang, Qian-Sheng Huang, Li Tian, Tian Li, Li T, Chen QX, Qing-Xi Chen, Qing‐Xi Chen
Fertility and sterility · 2009 · vol. 93(5) , pp. 1440–1447 · doi:10.1016/j.fertnstert.2009.01.107 · PMID:19268934 · W2059302153
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15-Epi-lipoxin A4 significantly reduced endometriotic lesion size and vascularization in a mouse model, indicating a potential therapeutic role in inhibiting endometriosis progression.

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Abstract

OBJECTIVE: To examine the pro-resolution actions of 15-epi-lipoxin A(4) (LXA(4)) on endometriotic lesions, on the concentrations and activities of matrix metalloproteinases (MMP-2 and MMP-9) in murine endometriosis. DESIGN: Prospective, vehicle-controlled experimental study. SETTING: Animal research facility. ANIMAL(S): BALB/c mice. INTERVENTION(S): Endometriosis (EM) was induced in 30 mice. Fifteen of them were administered LXA(4) for 24 days (LXA(4) group), whereas the other 15 served as a control group (EM group). Another 15 sham-operated mice (sham-operated group) were treated with vehicles. MAIN OUTCOME MEASURE(S): The weight of the endometriotic lesions was measured. The concentrations, mRNA, and activities of MMP-2 and MMP-9 were determined by enzyme-linked immunosorbent assay, quantitative real-time polymerase chain reaction, and gelatin zymography, respectively. RESULT(S): Compared with EM group, the weight of the endometriotic lesions was decreased, the concentrations of MMP-2 and MMP-9 dropped, the mRNA levels of MMP-2 and MMP-9 in the peritoneal fluid cells and the endometriotic lesions were reduced, and the activities of MMP-2 and MMP-9 were inhibited in the LXA(4) group. CONCLUSION(S): LXA(4) may inhibit the progression of endometriosis possibly by lowering the concentrations and the activities of MMP-2 and MMP-9.

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Condition tags

endometriosis

MeSH descriptors

Anti-Inflammatory Agents, Non-Steroidal Endometriosis Endometrium Lipoxins Animals Animals Anti-Inflammatory Agents, Non-Steroidal Anti-Inflammatory Agents, Non-Steroidal Anti-Inflammatory Agents, Non-Steroidal Ascitic Fluid Ascitic Fluid Ascitic Fluid Ascitic Fluid Disease Models, Animal Disease Models, Animal Disease Progression Disease Progression Down-Regulation Down-Regulation Endometriosis

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References (38)

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