Immunological Aspects of Good-quality Dysplasia of Mammary Glands at Women of Reproductive Age

Svitlana Gladenko
In: Family medicine · 2019 · pp. 144–146 · doi:10.30841/2307-5112.5-6.2019.194843 · W3008834489
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⚙ AI-generated summary by qwen3.7-flash, 2026-09-10 ⓘ

This study identified adenomyosis as a risk factor for good-quality mammary gland dysplasia in women of reproductive age, demonstrating that immunologic determinants play an essential role in the pathogenesis of this benign breast pathology.

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This study investigated the immunological aspects of benign mammary gland dysplasia in 90 women aged 22 to 45, comparing patients with diffuse or nodal forms against a control group. The researchers identified chronic extragenital diseases, smoking, early menarche, and specific gynecological conditions as risk factors for developing this breast pathology. The findings demonstrated that immunologic determinants serve as essential initial links in the pathogenesis of benign breast disease, necessitating their consideration in diagnostic and treatment algorithms. Relevance to endometriosis: adenomyosis is listed among the risk factors associated with benign mammary gland dysplasia, though the paper's primary focus remains on breast pathology rather than uterine disorders.

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Abstract

The objective: to study modern immunologic aspects of good-quality dysplasia of mammary glands at women of reproductive age.Materials and methods. Were surveyed 90 patients aged from 22 till 45 years which are divided into 3 groups on 30 women: 1 group (group of control) – the woman without pathology in mammary glands. The 2nd group included patients with diffuse form of good-quality dysplasia of mammary glands. The 3rd group was made by patients with a nodal form of a good-quality dysplasia of mammary glands. The complex the researches included clinical, immunologic and statistical methods.Results. Results of the conducted researches testify that it is possible to refer existence of chronic extragenital diseases, smoking, an early menarche to risk factors of development of a good-quality dysplasia of mammary glands, disturbances of a menstrual cycle, hysteromyoma and an adenomyosis, an artificial or spontaneous abortion. The research conducted by us proved that immunologic determinants play an essential role and are risk factors and an initial link of pathogenesis of benign pathology of mammary glands.Conclusion. The received results need to be considered when developing algorithm of diagnostic and treatment-and-prophylactic actions.
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Abstract

The objective: to study modern immunologic aspects of good-quality dysplasia of mammary glands at women of reproductive age.

Materials

and methods. Were surveyed 90 patients aged from 22 till 45 years which are divided into 3 groups on 30 women: 1 group (group of control) – the woman without pathology in mammary glands. The 2nd group included patients with diffuse form of good-quality dysplasia of mammary glands. The 3rd group was made by patients with a nodal form of a good-quality dysplasia of mammary glands. The complex the researches included clinical, immunologic and statistical methods. Results. Results of the conducted researches testify that it is possible to refer existence of chronic extragenital diseases, smoking, an early menarche to risk factors of development of a good-quality dysplasia of mammary glands, disturbances of a menstrual cycle, hysteromyoma and an adenomyosis, an artificial or spontaneous abortion. The research conducted by us proved that immunologic determinants play an essential role and are risk factors and an initial link of pathogenesis of benign pathology of mammary glands. Conclusion. The received results need to be considered when developing algorithm of diagnostic and treatment-and-prophylactic actions.##plugins.themes.bootstrap3.article.details## This work is licensed under a Creative Commons Attribution 4.0 International License. Authors retain the copyright and grant the journal the first publication of original scientific articles under the Creative Commons Attribution 4.0 International License, which allows others to distribute work with acknowledgment of authorship and first publication in this journal.

References

Шурпяк С.О., Пирогова В.І., 2018. Репродуктивне здоров’я і коморбідні стани. Аспекти діагностики, лікування і реабілітації. – Львів: Простір-М: 224. Hammad A.E., 2016. Women and health security. Wld Hlth Statist. Quart. 49(2):74-7. Вольфф М. фон, Штуте П., 2017. Гинекологическая эндокринология и репродуктивная медицина, пер. с нем. под ред. Е.Н. Андреевой. – М.: МЕД-пресс-информ: 512. Радзинский В.Е., 2011. Репродуктивное здоровье: Учеб. пособие. – М.: РУДН: 727. Запорожан В.М. та ін., 2013. Акушерство та гінекологія: у 4-х т.: національний підручник. – К.: ВСВ Медицина: 1032. Корнацька А.Г., Татарчук Т.Ф., Дубенко О.Д. 2017. Безплідність та доброякісні захворювання молочної залози. – К.: 271. Бабаева Н.А., Ашрафян Л.А., Антонова И.Б., Алешикова О.И., Ивашина С.В., 2017. Роль гормональных нарушений в канцерогенезе опухолей женской репродуктивной системы // Акушерство и гинекология: новости, мнения, обучение. 1:76-82.

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