Gamma-glutamyl transferase to high-density lipoprotein cholesterol ratio and endometriosis: a population-based study

Ziyang Zheng, Jiaqi Wu, Zhonghua Sun, Z Y Sun, Xin Li, Qingyang Shi, Mingzhang Xu
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology · 2026 · vol. 46(1) , pp. 2609485 · doi:10.1080/01443615.2025.2609485 · PMID:41494840 · W7118428569
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This population-based study found a significant positive association between the gamma-glutamyl transferase to high-density lipoprotein cholesterol ratio and endometriosis.

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Abstract

BACKGROUND: The gamma-glutamyl transferase (GGT) to high-density lipoprotein (HDL) ratio (GGT/HDL) has recently emerged as a potential biomarker for metabolic and liver diseases. This study aimed to investigate the association between GGT/HDL ratio and endometriosis using a population-based dataset from the National Health and Nutrition Examination Survey (NHANES). METHODS: Data from NHANES 1999 to 2006 were used to assess the relationship between the GGT/HDL ratio and endometriosis. The diagnosis of endometriosis was based on self-reported data from the Reproductive Health Questionnaire. The GGT/HDL ratio was calculated and Ln-transformed for analysis. Multivariable logistic regression and sensitivity analysis were used to estimate the odds ratio (OR) for endometriosis in relation to the GGT/HDL ratio. RESULTS: = 0.046). Sensitivity analyses including the use of original GGT/HDL value, the further adjustments of covariates, the exclusion of those with CVD and liver diseases confirmed the robustness of this association. CONCLUSIONS: This study found a significant positive association between the GGT/HDL ratio and endometriosis. Higher GGT/HDL levels may serve as a potential biomarker for identifying women at risk of endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Cholesterol, HDL Cholesterol, HDL Cholesterol, HDL Cholesterol, HDL Cholesterol, HDL Cholesterol, HDL Cholesterol, HDL Cholesterol, HDL Cholesterol, HDL Cholesterol, HDL Cholesterol, HDL Cholesterol, HDL Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (50)

Source provenance

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