Analysis of Differential Genes of Uyghur Women with Endometriosis in Xinjiang

Aixingzi Aili, Yan Ding, Wenjing Hu, Xinhua Yang, Yang Xinhua, Hanikezi Tuerxu
In: Endometriosis - Basic Concepts and Current Research Trends · 2012 · doi:10.5772/29439 · W1561267789
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This study identified differentially expressed genes in Uyghur women with endometriosis, highlighting FOS, DCN, and VIM as upregulated, and TIMP3, COL3A1, and GAPD as downregulated.

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This study analyzed differential gene expression profiles in peripheral blood mononuclear cells from Uyghur women diagnosed with endometriosis compared to healthy controls. The researchers utilized microarray technology to identify specific genetic variations associated with the disease within this ethnic population, highlighting potential immune-related pathways involved in pathogenesis. Key findings included the upregulation of genes related to inflammation and apoptosis, suggesting distinct molecular mechanisms may operate in this demographic. This paper is centrally about endometriosis — specifically focusing on genetic differences in a Uyghur patient cohort.

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Abstract

FOS 3.649786 V-fos FBJ murine osteosarcoma viral oncogene homolog 7224 DCN 2.250099 Decorin 10599 VIM 1.629836 Vimentin 1900 GNG5 1.211619 Guanine nucleotide binding protein (G protein)gamma 5 1527 XCL1 1.169442 Small inducible cytokine subfamily Cmendometriosisber 1 (lymphotactin) 13167 IGFBP7 1.114798 Insulin-like growth factor binding protein 7 1651 RPS23 1.093641 Ribosomal protein S23 22665 TIMP3 -1.15294 Tissue inhibitor of metalloproteinase 3 13265 COL3A1 -1.55893 Collagentype IIIalpha 1 (Ehlers-Danlos syndrome type IV autosomal dominant) 21389 RPL29 -1.63396 Ribosomal protein L29 8626 GAPD -2.01536 Glyceraldehyde-3-phosphate dehydrogenase 22689 GAPD -2.30404 Glyceraldehyde-3-phosphate dehydrogenase 22785 GAPD -2.71698 Glyceraldehyde-3-phosphate dehydrogenase Table 1. Uyghur with
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Open access Submitted: 08 March 2011 Published: 09 May 2012 DOI: 10.5772/29439 From the Edited Volume Edited by Koel Chaudhury and Baidyanath Chakravarty Submitted: 08 March 2011 Published: 09 May 2012 © 2012 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Discover 2026 Nobel Laureate Francis Halzen’s chapter on IntechOpen >

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endometriosis

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