Optimising Care For Endometriosis: New Therapeutic Options and Surgical Considerations — A Systematic Literature Review (SLR)

Parthasarathi Amirthalakshmi, Ghose Seetesh, Seetesh Ghose
In: Adolescência e Saúde · 2026 · pp. 1379–1390 · doi:10.67440/ahj.vi.2129 · W7213462973
Systematic review / meta-analysis OA: hybrid CC0
🔓 Open OA copy Full text JSON View on OpenAlex View at publisher
⚙ AI-generated summary by qwen3.7-flash, 2026-10-20 ⓘ

This systematic review synthesizes recent evidence on endometriosis management, finding that newer oral GnRH antagonists consistently reduce pain and improve quality of life while surgical outcomes depend heavily on technique to preserve ovarian reserve.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by qwen3.7-flash, 2026-09-27 · read from full text ⓘ

This systematic literature review evaluated recent advancements in therapeutic and surgical management for endometriosis, synthesizing data from fifteen clinical studies published between 2015 and 2025. The analysis found that newer oral gonadotropin-releasing hormone antagonists consistently reduced pelvic pain and improved quality of life, while surgical outcomes varied significantly based on the extent of the procedure and its impact on ovarian reserve. The authors emphasized that extensive surgical interventions are not always superior to less invasive techniques, highlighting the critical need for fertility-preserving approaches to protect reproductive potential. Ultimately, the paper argues for a patient-centered care model that integrates medical and surgical options to address symptom control, safety, and long-term well-being. This paper is centrally about endometriosis — specifically focusing on optimizing treatment strategies through a combination of new hormonal therapies and nuanced surgical considerations.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Endometriosis is a chronic gynaecological condition that is linked to pelvic pain, dysmenorrhea, infertility and poor quality of life (QoL) and now needs to be managed increasingly on an individual basis combining medical and surgical treatment. This systematic literature review assessed recent therapeutic and surgical considerations for the optimization of endometriosis treatment, focusing on pain control, QoL, fertility, ovarian reserve, recurrence, safety and postoperative outcomes. Original clinical studies published between 2015 to 2025 were identified through PubMed sand Google Scholar. Following duplications removal and eligibility screening, 15 studies were included and narratively synthesized based on therapeutic approaches, surgical management, reproductive outcomes, patient-reported outcomes and methodological quality. Newer oral gonadotropin-releasing hormone antagonists (elagolix, relugolix, and linzagolix) uniformly reduced dysmenorrhea and non-menstrual pelvic pain and improved functioning and QoL. Based on the surgical procedures, pain and QoL were also improved, but not in all cases the more extensive procedures were superior. It was demonstrated that the ovarian reserve was affected by surgical technique, underscoring the need for fertility preserving surgical techniques. Factors to consider for long-term results were recurrence, treatment safety, and repeat procedures. In summary, the ideal care of endometriosis must progress beyond the medical versus surgical dichotomy and exhibit a patient-centred approach that considers symptom management, safety, reproductive considerations and long-term QoL.
Full text 1,922 characters · extracted from oa-doi-fallback · click to expand
Optimising Care For Endometriosis: New Therapeutic Options and Surgical Considerations — A Systematic Literature Review (SLR) DOI: https://doi.org/10.67440/ahj.vi.2129Keywords: Endometriosis; GnRH antagonists; Surgical management; Fertility preservation; Quality of life.Abstract Endometriosis is a chronic gynaecological condition that is linked to pelvic pain, dysmenorrhea, infertility and poor quality of life (QoL) and now needs to be managed increasingly on an individual basis combining medical and surgical treatment. This systematic literature review assessed recent therapeutic and surgical considerations for the optimization of endometriosis treatment, focusing on pain control, QoL, fertility, ovarian reserve, recurrence, safety and postoperative outcomes. Original clinical studies published between 2015 to 2025 were identified through PubMed sand Google Scholar. Following duplications removal and eligibility screening, 15 studies were included and narratively synthesized based on therapeutic approaches, surgical management, reproductive outcomes, patient-reported outcomes and methodological quality. Newer oral gonadotropin-releasing hormone antagonists (elagolix, relugolix, and linzagolix) uniformly reduced dysmenorrhea and non-menstrual pelvic pain and improved functioning and QoL. Based on the surgical procedures, pain and QoL were also improved, but not in all cases the more extensive procedures were superior. It was demonstrated that the ovarian reserve was affected by surgical technique, underscoring the need for fertility preserving surgical techniques. Factors to consider for long-term results were recurrence, treatment safety, and repeat procedures. In summary, the ideal care of endometriosis must progress beyond the medical versus surgical dichotomy and exhibit a patient-centred approach that considers symptom management, safety, reproductive considerations and long-term QoL.

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (9)

Source provenance

openalex
last seen: 2026-11-08T06:02:16.207659+00:00
License: CC0 · commercial use OK