First successful pregnancy after addition of enoxaparin to sildenafil and etanercept immunotherapy in woman with fifteen failed IVF cycles - case report

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A woman with fifteen failed IVF cycles achieved a successful pregnancy and live birth on her sixteenth attempt following the addition of enoxaparin to sildenafil and etanercept immunotherapy.

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Abstract

PROBLEM: Does addition of enoxaparin to sildenafil and etanercept immunotherapy improve IVF outcome? METHODS: Report of a striking case with 15 IVF failures. RESULT: When enoxaparin was added, the 16th IVF cycle generated a healthy male baby. CONCLUSIONS: Combination therapy that includes a heparin may allow successful IVF outcome and this issue merits further study.

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Condition tags

endometriosis

MeSH descriptors

Anticoagulants Enoxaparin Fertilization in Vitro Fertilization in Vitro Immunoglobulin G Immunotherapy Piperazines Receptors, Tumor Necrosis Factor Sulfones Tumor Necrosis Factor-alpha Anticoagulants Anticoagulants Cytotoxicity, Immunologic Cytotoxicity, Immunologic Cytotoxicity, Immunologic Drug Therapy, Combination Drug Therapy, Combination Endometriosis Endometriosis Endometriosis

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Source provenance

europepmc
last seen: 2026-10-25T09:32:14.900964+00:00
pubmed
last seen: 2026-10-08T21:07:26.396758+00:00
unpaywall
last seen: 2026-05-14T19:30:52.867331+00:00
License: public-domain-us · commercial use OK · attribution required
Courtesy of the U.S. National Library of Medicine