Design and implementation of interventions to improve sexual health of women with endometriosis: A mixed-methods study protocol with an interventional design

In: International Journal of Reproductive BioMedicine (IJRM) · 2026 · vol. 24(4) · doi:10.18502/ijrm.v24i4.21170 · W7163187724
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This study protocol outlines a mixed-methods approach to design and implement interventions for improving women's sexual health in endometriosis, followed by an RCT to evaluate their effectiveness.

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This paper describes the design and implementation plan for an interventional mixed-methods study aimed at improving the sexual health of women with endometriosis, outlining high-level methodology for how the intervention will be developed and evaluated. The study is presented as a protocol rather than results-producing research, so the primary “finding” is the planned approach to collecting both quantitative and qualitative data during the intervention. A key limitation is that, as a protocol, it does not report outcomes or efficacy at the time of publication. This paper is centrally about endometriosis — it focuses specifically on designing an intervention to improve sexual health in women with endometriosis.

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Abstract

Background: Endometriosis has potential negative effects on the fertility, mental, and sexual health of women. Since the conducted studies have not comprehensively addressed the needs and strategies to improve sexual health, and to design the necessary programs and interventions for this group of women. Objective: The present study aims to design and implement interventions to improve sexual health of women with endometriosis. Materials and Methods: This sequential mixed-methods study comprises 4 phases. Phase 1 is a qualitative study using semi-structured interviews to explore needs and strategies from the perspectives of women with endometriosis and healthcare providers. Phase 2 involves a systematic review to identify additional evidence-based strategies. Phase 3 integrates findings from phases 1 and 2 with prioritization by a multidisciplinary expert panel using the Delphi technique, to develop a comprehensive intervention program. Phase 4 is a randomized controlled trial to evaluate the effectiveness of the developed intervention on sexual function and sexual quality of life compared to routine care. Conclusion: This protocol aims to develop a comprehensive, evidence-based care program integrating qualitative insights, systematic review findings, and multidisciplinary expert opinions, and to evaluate its effectiveness in improving the sexual health of women with endometriosis.
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Publication International Journal of Reproductive BioMedicine (IJRM) Record type Journal article Published 2 June 2026 Authors Tahmineh Farajkhoda | Shahla Mohammadkhani | Mohammadtaghi Sarebanhassanabadi | Atiyeh Javaheri | Fatemeh ZareMobini The publisher of this work supports multiple resolution. The work is available from the following locations: {'doi': '10.18502/ijrm.v24i4.21170', 'member_id': '7770', 'member': 'Knowledge E DMCC', 'container-title': 'International Journal of Reproductive BioMedicine (IJRM)', 'primary-resource': 'https://knepublishing.com/index.php/ijrm/article/view/21170', 'tld': 'knepublishing.com', 'clearbit-logo': '/static/no_logo.svg', 'coaccess': [], 'multiple-resolution': [{'url': 'http://ijrm.ir/article-1-3551-en.html', 'tld': 'ijrm.ir', 'clearbit-logo': '/static/no_logo.svg'}], 'type': 'JOURNAL ARTICLE', 'published_date': '2 June 2026', 'publication': 'International Journal of Reproductive BioMedicine (IJRM)', 'title': 'Design and implementation of interventions to improve sexual health of women with endometriosis: A mixed-methods study protocol with an interventional design', 'name': None, 'id': None, 'location': None, 'display_doi': 'https://doi.org/10.18502/ijrm.v24i4.21170', 'grant_info': None, 'grant_info_funders': None, 'grant_info_funder_ids': '', 'grant_info_type': None, 'multiple_lead_investigators': [], 'multiple_co_lead_investigators': [], 'multiple_investigators': [], 'finances': [], 'project_description': None, 'award_amount': None, 'award_start': None, 'funding_scheme': None, 'internal_award_number': None, 'editors': None, 'authors': 'Tahmineh Farajkhoda | Shahla Mohammadkhani | Mohammadtaghi Sarebanhassanabadi | Atiyeh Javaheri | Fatemeh ZareMobini', 'chairs': None, 'supplementary_ids': None} https://doi.org/10.18502/ijrm.v24i4.21170 JSON XML

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endometriosis

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