Xue Ping Tablets treat abnormal uterine bleeding via VEGF-ERK1/2 pathway
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Xue Ping tablets reduced abnormal uterine bleeding in a rat model by inhibiting inflammatory factors within the VEGF-ERK1/2 pathway.
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Abstract
Objective: To investigate the protective effects against abnormal uterine bleeding (AUB) and possible mechanisms of Xue Ping tablets (XPT) using a rat model. Methods: A total of 58 unmated female and 25 male SPF SD rats aged 8-9 weeks were selected. Eight unmated female rats were selected as the blank control group according to the complete random method. The other 50 rats were mated in a female/male ratio of 2:1. In the morning after mating, vaginal smears were collected. Presence of vaginal plug or sperm was regarded as the first day of pregnancy. All pregnant rats were given 8.3 mg/kg of mifepristone by gavage at 8:00 a.m. and 100 μg/kg misoprostol by gavage at 6:00 p.m. on the seventh day of pregnancy to induce incomplete abortion, thereby establishing a rat model of AUB. Forty rats were randomly divided into model, low- (220 mg/kg), medium- (441 mg/kg), high-dose (882 mg/kg) XPT, and positive control groups. The positive group was given 130 mg/kg Gong Xue Ning (GXN). The model group and the blank group were given an equal amount of distilled water. Results: < 0.05). Conclusions: XPT could reduce AUB by inhibiting the inflammatory factors involved in the VEGF-ERK1/2 pathway.
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References (24)
- Estrogen up-regulates MMP2/9 expression in endometrial epithelial cell via VEGF-ERK1/2 pathway via openalex
- Evaluation and management of abnormal uterine bleeding. via openalex
- Expression deregulation of matrix metalloproteinases and vasoconstriction related genes in Pakistani females with abnormal uterine bleeding via openalex
- Expression of vascular endothelial growth factor A isoforms is dysregulated in women with endometriosis via openalex
- Progesterone and abnormal uterine bleeding/menstrual disorders via openalex
- Protective effect of Clinopodium chinense (Benth.) O. Kuntze against abnormal uterine bleeding in female rats via openalex
- Role of angiogenesis in adenomyosis-associated abnormal uterine bleeding and subfertility: a systematic review via openalex
- The bimodal role of matrix metalloproteinases and their inhibitors in etiology and pathogenesis of endometriosis (Review) via openalex
- Uterine bleeding: how understanding endometrial physiology underpins menstrual health via openalex
- W6840310948 via openalex
- doi:10.3390/ijms21249739 via openalex
- doi:10.19540/j.cnki.cjcmm.20211230.701 via openalex
- doi:10.1002/rmb2.12342 via openalex
- doi:10.1002/ijgo.12709 via openalex
- doi:10.1093/biolre/ioy231 via openalex
- doi:10.3390/jcm11195836 via openalex
- doi:10.1016/j.jep.2019.112230 via openalex
- doi:10.1002/ijgo.12666 via openalex
- doi:10.1016/j.cell.2019.01.021 via openalex
- W3211873538 via openalex
- W4226374900 via openalex
- W4286933261 via openalex
- W6810508295 via openalex
- W6839276762 via openalex
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