Association between bleeding tendency and endometriosis (Presentation of two cases)

Nasim Valizadeh, Haleh Ayatollahi, F Bromand
In: Journal of Applied Hematology · 2013 · vol. 4(3) , pp. 118 · doi:10.4103/1658-5127.123315 · W2066364934
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This paper presents two cases of endometriosis accompanied by bleeding disorders, specifically mild hemophilia A and Von Willebrand Disease, both manifesting with heavy menstrual bleeding.

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This case report describes a five-year-old girl with sickle cell disease who presented with acute altered sensorium and reduced responsiveness. Diagnostic imaging revealed basilar artery thrombosis and pontine infarction, which were confirmed as the initial manifestation of the HbSS genotype through hemoglobin electrophoresis. The patient underwent exchange transfusion followed by hydroxyurea therapy, resulting in gradual improvement and a modified Rankin Scale score of 3 at discharge. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Background: Endometriosis is implantation of normal endometrial mucosa in the ectopic sites. Literature review suggests that microscopic internal bleeding follows by revascularization and fibrosis is possible mechanism for endometriosis. There are a few reports regarding association of endometriosis and bleeding disorders. We present two cases with bleeding tendency, one with mild hemophilia A and another with Von Willebrand Disease (VWD) that were presented with heavy menses and endometriosis.
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Basilar Artery Thrombosis with Pontine Infarction as the Initial Presentation of Sickle Cell Disease in a Five-Year-Old Girl: A Case Report Abstract: Stroke is a well-known complication of sickle cell disease (SCD), typically involving the anterior circulation. Posterior circulation stroke as the initial manifestation of SCD is rare. This case highlights the diagnostic challenge posed by nonfocal neurological symptomtables in paediatric posterior circulation ischemia. A 5-year-old girl presented with acute onset altered sensorium and reduced responsiveness. Magnetic resonance imaging (MRI) of the brain demonstrated diffusion restriction in the pons. MR angiography (MRA) showed absent opacification of the basilar artery. Laboratory evaluation showed anemia and elevated reticulocyte count, with hemoglobin electrophoresis confirming HbSS genotype. Exchange transfusion was performed, following confirmation of HbSS followed by initiation of hydroxyurea for secondary stroke prevention. The child showed gradual improvement in sensorium, with a modified Rankin Scale score of 3 at discharge. Posterior circulation stroke can be the first manifestation of SCD. Early MRI with MRA and prompt transfusion-based therapy are critical.

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Condition tags

endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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