Ovarian endometrioma associated with very high serum CA-125 levels.
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This paper reports a case of unilateral ovarian endometrioma associated with a very high serum CA-125 level which normalized after surgical excision of the tumor.
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Abstract
CA-125 is a 220-kD cell surface glycoprotein present in over 80% of non-mucinous epithelial ovarian carcinomas and it occurs in the serum of healthy males and females at low concentrations (< 35 U/mL). Serum CA-125 concentration may also be moderately elevated in several benign conditions, such as pelvic inflammatory disease, uterine fibroids, pregnancy, spontaneous abortion with chromosomal abnormality, and especially in endometriosis. However, serum CA-125 concentration is seldom > 100 IU/ml in endometriosis. In this paper, we present a patient with unilateral ovarian endometrioma associated with abnormally high serum CA-125 level (> 6000 U/mL) and after excision of the ovarian tumor, the CA-125 levels returned to normal. Our case further emphasizes the association of high levels of CA-125 with benign gynecologic conditions and we discussed the possible explanations for this abnormal elevation of CA-125 levels.
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Cited by (7)
- Enhancing endometrioma management: Diagnostic biomarkers and predictive outcomes in Ruptured vs. Non-Ruptured cases 2024
- Adnexal mass with extremely high levels of CA-125 and CA19-9 but normal Human Epididymis Protein 4 (HE4) and Risk of Ovarian Malignancy Algorithm (ROMA): Endometriosis or ovarian malignancy? A case report 2018
- Elevated CA 125 in a CASE of Leaking Endometrioma 2018
- Correlation of CA-125 serum level and clinico-pathological characteristic of patients with endometriosis 2016
- Ruptured Endometrioma Presenting as Acute Abdomen with Highly Raised Serum CA-125 Levels: A Case Report 2011
- CA 125 serum values in surgically treated endometriosis patients and its relationships with anatomic sites of endometriosis and pregnancy rate 2010
- Adenomyosis With Extremely Elevated CA 125 Levels 2009
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- europepmc
- last seen: 2026-06-04T01:30:01.192114+00:00
- openalex
- last seen: 2026-06-04T00:00:01.174412+00:00
- pubmed
- last seen: 2026-05-13T22:12:44.121522+00:00
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