Alpha‐fetoprotein producing ovarian clear cell carcinoma with a neometaplasia to hepatoid carcinoma arising from endometriosis: A case report

Yoshiki Takahashi, Haruta Mogami, Shinshichi Hamada, Koji Urasaki, Ikuo Konishi
Journal of Obstetrics and Gynaecology Research · 2011 · vol. 37(12) , pp. 1842–1846 · doi:10.1111/j.1447-0756.2011.01622.x · PMID:21827573 · W2152617205
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This case report describes an alpha-fetoprotein producing ovarian clear cell carcinoma arising from endometriosis with a hepatoid carcinoma component, which responded well to chemotherapy upon recurrence.

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Abstract

We present a rare case of alpha-fetoprotein (AFP) producing ovarian clear cell carcinoma. This is the first report of a clear cell ovarian carcinoma with hepatoid carcinoma arising from endometriosis. A 54-year-old menopausal woman had a primary ovarian carcinoma of International Federation of Gynecology and Obstetrics stage IIIc. Serum level of AFP was 4195 ng/mL. Histological examination revealed clear cell adenocarcinoma arising from endometriosis with hepatoid carcinoma. Metastatic liver and lymph node tumors were found after 25 months from the first surgery. However, the patient's serum AFP was within normal limits. The recurrent and metastatic tumors disappeared in response to combined liposomal doxorubicin and carboplatin chemotherapy. She has had a disease-free survival of 4 years. In conclusion, the patient had a clear cell ovarian carcinoma with hepatoid carcinoma arising clearly from endometriosis. The recurrent tumors did not show a component of hepatoid carcinoma. Therefore, it is possible to expect better survival with good sensitivity to chemotherapy.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Adenocarcinoma, Clear Cell alpha-Fetoproteins Carcinoma, Endometrioid Carcinoma, Hepatocellular Endometriosis Neoplasms, Multiple Primary Ovarian Neoplasms Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell alpha-Fetoproteins Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Hepatocellular Carcinoma, Hepatocellular Endometriosis Endometriosis Female Humans Middle Aged

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