Angiogenic activity and IL‐8 concentrations in peritoneal fluid and sera in endometriosis
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Abstract
OBJECTIVES: During menstruation endometrial fragments are transported into the peritoneal cavity where they form endometriotic lesions. Angiogenesis is proposed as one of the mechanisms in endometriosis pathogenesis. The aim of the study was to determine the angiogenic activity and interleukin 8 concentrations in peritoneal fluid and sera in endometriosis. METHODS: Angiogenesis was determined in cutaneous assay in Balb/c mice; IL-8 concentrations were measured by ELISA test in sera and peritoneal fluid of 32 control and 56 endometriosis patients. Wilcoxon and Mann-Whitney tests and Spearman rank correlations were used in statistical analysis. RESULTS: Peritoneal fluid and sera from the examined group had higher angiogenic activity and interleukin 8 concentrations. There was correlation found between AFS and neovascularization induced by sera and PF of patients with peritoneal lesions. CONCLUSIONS: Angiogenesis plays an important role in pathogenesis of endometriosis. Although IL-8 takes part in neovascularization, there are other factors modulating angiogenesis in endometriosis.
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Cited by (31)
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- Endometriosis-Associated Angiogenesis and Anti-angiogenic Therapy for Endometriosis 2022
- Immunopathogenesis of endometriosis: An overview of the role of innate and adaptive immune cells and their mediators 2022
- The Effect of Novel Medical Nonhormonal Treatments on the Angiogenesis of Endometriotic Lesions 2021
- Vascularization of endometrial tissue in abdominal cavity – the most important link in the pathogenesis of endometriosis or its vulnerable spot in terms of treatment? (review of literature) 2019
- Local and systemic levels of cytokines and danger signals in endometriosis-affected women 2018
- Basic mechanisms of vascularization in endometriosis and their clinical implications 2018
- Novel Drug Targets with Traditional Herbal Medicines for Overcoming Endometriosis 2018
- Synergistic effect of regulatory T cells and proinflammatory cytokines in angiogenesis in the endometriotic milieu 2017
- Blood biomarkers for the non-invasive diagnosis of endometriosis 2016
- DEVELOPMENT OF A DOMESTIC ANIMAL MODEL OF ENDOMETRIOSIS 2016
- Progress on macrophage's proinflammatory products as markers of acute endometriosis 2015
- The Implication of Angiogenesis in Endometriosis 2014
- Investigation of diagnostic potentials of nine different biomarkers in endometriosis 2014
- Role of Nerve Fibres in Endometriosis 2014
- Can chemokines be used as biomarkers for endometriosis? A systematic review 2013
- Angiogenesis and Endometriosis 2013
- Macrophage Migration Inhibitory Factor Antagonist Blocks the Development of Endometriosis In Vivo 2012
- Novel Therapies Targeting Endometriosis 2011
- Diagnosis of Endometriosis: Biomarkers 2011
- A baboon model for endometriosis: implications for fertility 2006
- Effects of combined 17β-estradiol with TCDD on secretion of chemokine IL-8 and expression of its receptor CXCR1 in endometriotic focus-associated cells in co-culture 2006
- Decreased peritoneal concentrations of interleukin-15 in women with advanced stage endometriosis 2006
- Susceptibility to ovarian endometriosis in Polish population is not associated with HLA-DRB1 alleles 2005
- Role of immunologic and inflammatory factors in the development of endometriosis: indications for treatment strategies 2005
- The “neurologic hypothesis”: a new concept in the pathogenesis of the endometriosis? 2005
- Role of immunologic and inflammatory factors in the development of endometriosis: indications for treatment strategies 2005
- Novel targets for the treatment of endometriosis 2004
- Proteomic approaches in endometriosis research 2004
- Immunology of endometriosis 2004
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