Нарушения процессов регуляции ангиогенеза и склерозирования при гиперпластических процессах эндометрия

In: Акушерство, гинекология и репродукция · 2012 · vol. 6(3) · W196855031
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Pathomorphological and immunohistochemical analysis of endometrial tissue reveals that elevated VEGF, TGFβ1, fibronectin, and lysyl oxidase levels in atypical hyperplasia and chronic endometritis indicate cellular hypoxia and serve as negative prognostic factors.

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Abstract

Pathomorphological and immunohistochemical studies of endometrium were performed. The higher proliferative activity of the VEGF and the higher production of transformation growth factor β1 (TGFβ1), fibronectin and liziloxydaza in patiens with atypical hyperplasia of endometrium and chronic endometritis testifies the presence of cellular hypoxia, disturbance of intercellular and extracellular interaction and can be considered as the negative prognostic factor.

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