Endotoxemia and enterosorption in obstetric and gynecological practice

И. Б. Манухин, T. P. Kraposhina, S.P. Kerimova, A.V. Khovanov
In: Voprosy ginekologii, akušerstva i perinatologii · 2021 · vol. 20(2) , pp. 94–101 · doi:10.20953/1726-1678-2021-2-94-101 · W3178497346
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This review examines intestinal endotoxin's role in obstetric and gynecological diseases, analyzing the therapeutic effects of enterosorbent polymethylsiloxane polyhydrate for conditions including endometriosis.

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This review examines the role of intestinal endotoxins in the pathogenesis of various obstetric and gynecological conditions and evaluates the therapeutic potential of enterosorption using polymethylsiloxane polyhydrate. The authors analyze over thirty years of clinical experience to assess how this enterosorbent corrects endotoxin aggression across a range of disorders, including pre-eclampsia, pregnancy loss, and chronic pelvic inflammatory disease. Key findings highlight the mechanisms by which the drug exerts its medical and prophylactic effects on these systemic and local inflammatory processes. Relevance to endometriosis: listed as one indication for treatment with enterosorbents alongside other gynecological diseases such as chronic pelvic inflammatory disease.

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Abstract

The review considers the role of intestinal endotoxin in the pathogenesis of a number of obstetric and gynecological diseases, as well as the results of their treatment with the use of enterosorption in order to correct endotoxin aggression. The well-known methods for determining anti-endotoxin immunity and modern classification of enterosorbents were presented. The analysis of the main results of more than 30 years experience in the use of enterosorbent polymethylsiloxane polyhydrate was conducted, taking into account the mechanisms of its medical and prophylactic effects in the treatment of pre-eclampsia, arterial hypertension of pregnant women, miscarriage, endometriosis, chronic pelvic inflammatory disease, urogenital disorders, vulvar lichen sclerosus. The evaluation of therapeutic properties of the drug polymethylsiloxane polyhydrate was carried out, and prospective directions for its further use in obstetric and gynecological practice were planned. Key words: pregnancy loss, pre-eclampsia, vulvar lichen sclerosus, endometriosis, endotoxin, endotoxin aggression, enterosgel
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Endotoxemia and enterosorption in obstetric and gynecological practice Igor B. Manukhin / Tatiana P. Kraposhina / Saida P. Kerimova / Alexander V. Khovanov / The review considers the role of intestinal endotoxin in the pathogenesis of a number of obstetric and gynecological diseases, as well as the results of their treatment with the use of enterosorption in order to correct endotoxin aggression. The well-known methods for determining anti-endotoxin immunity and modern classification of enterosorbents were presented. The analysis of the main results of more than 30 years experience in the use of enterosorbent polymethylsiloxane polyhydrate was conducted, taking into account the mechanisms of its medical and prophylactic effects in the treatment of pre-eclampsia, arterial hypertension of pregnant women, miscarriage, endometriosis, chronic pelvic inflammatory disease, urogenital disorders, vulvar lichen sclerosus. The evaluation of therapeutic properties of the drug polymethylsiloxane polyhydrate was carried out, and prospective directions for its further use in obstetric and gynecological practice were planned. Key words: pregnancy loss, pre-eclampsia, vulvar lichen sclerosus, endometriosis, endotoxin, endotoxin aggression, enterosgel For citation: Manukhin I.B., Kraposhina T.P., Kerimova S.P., Khovanov A.V. Endotoxemia and enterosorption in obstetric and gynecological practice. Vopr. ginekol. akus. perinatol. (Gynecology, Obstetrics and Perinatology). 2021; 20(2): 94–101. (In Russian). DOI: 10.20953/1726-1678-2021-2-94-101

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