Correlation between MRNA IL1Β and type, duration of infertility in women with endometriosis on the stage preparing to assisted reproductive technologies using probiotics
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Abstract
OBJECTIVE: Aim: To investigate the correlations between the level of IL1β mRNA gene expression and the type and duration of infertility and to study the levels of IL1β mRNA gene expression in women with endometriosis associated with infertility. PATIENTS AND METHODS: Materials and Methods: For mRNA gene expression analysis IL1β and determination of relative normalized mRNA expression IL1β used the real-time reverse transcription polymerase chain reaction method (RT-PCR).. Examined group consists of 30 infertile women undergoing assisted reproductive technologies. The main group consisted of 20 women diagnosed with endometriosis undergoing assisted reproductive technologies. The control group consisted of 10 healthy women. RESULTS: Results: In the main group, the level of IL1β mRNA gene expression before preparing was 26.7877±0.01, which was significantly higher than the level after preparing (0.1610±0.01* ). Analized results, it's found out that Mean level of mRNA IL1β in women with endometriosis associated infertility 1-st degree is 8.53 c.u., at the same time Mean level of mRNA IL1β in women with endometriosis associated infertility 2-nd degree is 1.0 c.u. CONCLUSION: Conclusions: The inclusion of probiotics in a comprehensive regimen of preparation for assisted reproductive technologies leads to a noticeable improvement in the patient's well-being.
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Cites (4)
- Endometriosis with infertility: A comprehensive review on the role of immune deregulation and immunomodulation therapy 2020
- Biomarkers of endometriosis 2023
- Seven Hormonal Biomarkers for Diagnosing Endometriosis: Meta-Analysis and Adjusted Indirect Comparison of Diagnostic Test Accuracy 2019
- Serum Levels of Interleukins in Endometriosis Patients: A Systematic Review and Meta-analysis 2024
References (9)
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- europepmc
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- openalex
- last seen: 2026-06-04T00:00:01.174412+00:00
- pubmed
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