Psychoimmune Interactions in Women of Reproductive Age with Endometriosis

Р. Ф. Насырова, R F Nasyrova, L S Sotnikova, Л. С. Сотникова, N V Baystrukova, G V Krivoschchekova, V V Novitsky, I E Kupriyanova, V. Semke, V Ya Semke, И. О. Наследникова, I O Naslednikova, A N Baykov
Bulletin of experimental biology and medicine · 2011 · vol. 152(1) , pp. 93–97 · doi:10.1007/s10517-011-1463-0 · PMID:22803050 · W2013349772
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

This study examined psychoimmune interactions in women with endometriosis, revealing immunological shifts and correlations between mental state and immunopathogenesis, indicating a psychoneuroimmune basis for the condition.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

The paper studied psychoimmune interactions in women of reproductive age with endometriosis, focusing on immunological changes in T-cellular immunity and associated cytokine production. It reports pronounced immunological shifts marked by imbalanced pro-inflammatory cytokines (IL-1β, IL-2, IFN-γ) and anti-inflammatory cytokine IL-4, along with significant correlations between the severity of mental shifts and immunopathogenetic factors. A key limitation is that the available text describes these findings without detailing study design specifics, sample characteristics, or measurement methods. This paper is centrally about endometriosis — it examines psychoneuroimmune interactions in women with endometriosis and links mental changes to cytokine and immunopathogenetic alterations.

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Psychoimmune interactions were studied in women of reproductive age with endometriosis. Pronounced immunological shifts manifested in a shift of the T-cellular immunity, resulting in imbalanced production of pro- (IL-1β, IL-2, IFN-γ) and anti-inflammatory (IL-4) cytokines. Significant correlations between the severity of mental shifts and immunopathogenetic factors in the studied patient population demonstrated the psychoneuroimmune nature of endometriosis. Similar content being viewed by others References E. K. Ailamazyan, M. I. Yarmolinskaya, N. Yu. Shved, et al., Vestn. Rossiisk. Voen. Med. Akad., No. 2, 16–22 (2009). Yu. A. Aleksandrovskii and V. P. Chekhonin, Clinical Immunology of Borderline Mental Disorders [in Russian], Moscow (2005). V. P. Baskakov, Yu. V. Tsvelev, and E. F. Kira, The Endometrioid Disease [in Russian], St. Petersburg (2002). G. N. Kryzhanovskii, S. V. Magaeva, S. V. Makarov, et al., Neuroimmunopathology [in Russian], Moscow (2003). D. M. Mendelevich and V. D. Mendelevich, Nevrol. Vestn., 25, Nos. 1–2, 104–108 (1993). Psychotherapeutic Encyclopedia, Ed. B. D. Karvasarskii [in Russian], St. Petersburg (1998). V. Ya. Semke, E. D. Schastnyi, and G. G. Simutkin, Affective Disorders [in Russian], Tomsk (2004). H. O. Besedovsky and A. D. Rey, Brain Behav. Immun., 21, No. 1, 33–44 (2007). R. Dantzer, Ibid., 15, No. 1, 7–24 (2001). M. R. Irwin, Ibid., 22, No. 2, 129–139 (2008). M. R. Irwin and A. H. Miller, Ibid., 21, No. 4, 374–383 (2007). G. Jones, C. Jenkinson, N. Taylor, et al., Hum. Reprod., 21, No. 10, 2686–2693 (2006). D. Kerr, C. Krishnan, M. L. Pucak, and J. Carmen, Int. Rev. Psychiatry, 17, No. 6, 443–449 (2005). E. L. Poleshuk, M. J. Bair, K. Kroenke, et al., Psychosomatics, 50, No. 3, 270–276 (2009). M. Rauchfuss, H. Kentenich, F. Siedentopf, and G. Danzer, J. Psychosom. Obstet. Gynaecol., 26, No. 2, 85–91 (2005). F. Siedentopf, N. Tariverdian, M. Rucke, et al., Am. J. Reprod. Immunol., 60, No. 5, 449–461 (2008). Author information Authors and Affiliations Corresponding author Additional information Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 152, No. 7, pp. 100–105, July, 2011 Rights and permissions About this article Cite this article Nasyrova, R.F., Sotnikova, L.S., Baystrukova, N.V. et al. Psychoimmune Interactions in Women of Reproductive Age with Endometriosis. Bull Exp Biol Med 152, 93–97 (2011). https://doi.org/10.1007/s10517-011-1463-0 Received: Published: Issue date: DOI: https://doi.org/10.1007/s10517-011-1463-0

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometriosis Adolescent Adult Antigens, CD Antigens, CD Anxiety Anxiety Anxiety Anxiety Case-Control Studies Comorbidity Cytokines Cytokines Depression Depression Depression Depression Endometriosis Endometriosis

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