Stem cell and endometriosis: new knowledge may be producing novel therapies.

Jing Yang, Fengying Huang
International journal of clinical and experimental medicine · 2014 · vol. 7(11) , pp. 3853–8 · PMID:25550893 · W2174135646
article OA: green CC0 ⤵ 15 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This review summarizes recent findings on the presence and potential contribution of stem cells, including endometrial and mesenchymal stem cells, to the etiology of endometriosis.

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Abstract

The human endometrium is a dynamic tissue, which undergoes cycles of growth and regression with each menstrual cycle. Adult progenitor stem cells are likely responsible for this remarkable regenerative capacity; these same progenitor stem cells may also have an enhanced capacity to generate endometriosis if shed in a retrograde fashion. The progenitor stem cells reside in the uterus, and, however, may also travel from other tissues such as bone marrow to repopulate the progenitor population. Mesenchymal stem cells are also involved in the pathogenesis of endometriosis and may be the principle source of endometriosis outside of the peritoneal cavity when they differentiate into endometriosis in ectopic locations. The present short review mainly summarizes the latest observations contributing to the current knowledge regarding the presence and the potential contribution of stem cells in the etiology of endometriosis. All these data can have clinical implications and provide a basis for new potential therapeutic applications.

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Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (38)

Cited by (15)

SciLite annotations

organisms 8
human human noordeloos 2009062 parmelia tominii mus sp. transgenic mice tobacco multicellular animals
chemicals 4
estrogen sorafenib bazedoxifene estrone

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