Association of Peroxisome Proliferator‐Activated Receptor‐Gamma 2 Pro12Ala Polymorphism with Advanced‐Stage Endometriosis

Kyu Ri Hwang, Young Min Choi, Jong Mee Kim, Gyoung Hoon Lee, Jinju Kim, Jin Ju Kim, Soo Jin Chae, Shin Yong Moon
American journal of reproductive immunology (New York, N.Y. : 1989) · 2010 · vol. 64(5) , pp. 333–338 · doi:10.1111/j.1600-0897.2010.00882.x · PMID:20560917 · W2103492138
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Abstract

PROBLEM: To investigate whether the peroxisome proliferator-activated receptor (PPAR)-γ2 Pro12Ala polymorphism is associated with a risk of advanced-stage endometriosis in a Korean population. METHODS OF STUDY: Case-control study in a collective of 446 patients and 427 controls. The Pro12Ala polymorphism of PPAR-γ2 gene was genotyped using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis. RESULTS: The distribution of the PPAR-γ2 Pro12Ala polymorphism was different between the advanced-stage endometriosis group and the control group (non-CC rates were 5.2% for patients with advanced endometriosis and 10.1% for the control group, respectively, P = 0.006). The frequency for the Ala-12 allele variant was significantly lower in patients with advanced stage of endometriosis (2.7%) than in the control group (5.3%) (P = 0.006). CONCLUSION: These findings suggest that the PPAR-γ2 Pro12Ala polymorphism is associated with advanced-stage endometriosis in the Korean population. Unlike results from other studies reported so far, the Ala-12 allele may have protective effects against advanced-stage endometriosis in the Korean population.

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mesh:D004715endometriosis

MeSH descriptors

Endometriosis PPAR gamma Alleles Case-Control Studies Chi-Square Distribution DNA DNA DNA Endometriosis Endometriosis Female Genetic Variation Humans Polymerase Chain Reaction Polymorphism, Restriction Fragment Length Polymorphism, Single Nucleotide PPAR gamma PPAR gamma

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