Subcutaneously administered Repronex in female patients undergoing in vitro fertilization is as effective and well tolerated as intramuscular menotropin treatment. Repronex SC, IVF Study Group

Gocial B, B Gocial, Benjamin Gocial, W R Keye, Keye Wr, William R. Keye, Seymour Fein, S H Fein, Fein SH, Ronald V. Nardi, R V Nardi, Nardi RV
Fertility and sterility · 2000 · vol. 74(1) , pp. 73–79 · doi:10.1016/s0015-0282(00)00605-1 · PMID:10899500 · W1922721494
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Subcutaneous Repronex administration was found to be as effective and well-tolerated as intramuscular menotropin for ovarian stimulation in women undergoing in vitro fertilization.

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Abstract

OBJECTIVE: To determine the efficacy and safety of Repronex SC as compared with Repronex IM and Pergonal IM in patients undergoing IVF. DESIGN: Open-label, randomized, parallel-group, multicenter study. SETTING: Fifteen academic and private fertility clinics with IVF experience. PATIENT(S): Premenopausal women with regular ovulatory menstrual cycles undergoing IVF for infertility attributable to tubal factors, endometriosis (stage I or II), or unknown factors. INTERVENTION(S): Down-regulation with leuprolide acetate followed by up to 12 days of treatments with gonadotropins, hCG administration, oocyte retrieval, and embryo transplant. MAIN OUTCOME MEASURE(S): Mean number of oocytes retrieved, chemical, clinical, and continuing pregnancies, incidence of oocyte retrieval and embryo transfer, and peak serum E2 concentrations. RESULT(S): There were no significant differences among the treatment groups except for a higher percentage of continuing pregnancies in the Repronex SC group. Gonadotropin therapy was well tolerated in all three treatment groups. The Repronex SC group had a significantly higher incidence of transient mild/moderate injection site reactions during the first few days of therapy. CONCLUSION(S): Repronex SC is comparable in therapeutic effectiveness and safety to Repronex IM and Pergonal IM in patients undergoing IVF and provides an alternative route of injection for self-administration of gonadotropin.

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MeSH descriptors

Fertility Agents, Female Fertilization in Vitro Fertilization in Vitro Gonadotropins Adolescent Adolescent Adult Adult Down-Regulation Down-Regulation Embryo Transfer Embryo Transfer Female Female Fertility Agents, Female Fertility Agents, Female Fertility Agents, Female Gonadotropins Gonadotropins Gonadotropins

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