Neferine mediated TGF-β/ERK signaling to inhibit fibrosis in endometriosis.
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Neferine treatment of endometriosis cells inhibited proliferation, invasion, and metastasis by regulating the TGF-β/ERK signaling pathway to reduce fibrosis.
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Abstract
OBJECTIVE: cell experiments. METHODS: and treated with Neferine to detect cell viability and the effects of invasion and metastasis. RESULTS: , which is required for the fibrosis process of endometriosis. Neferine also significantly inhibited the proliferation, invasion and metastasis ability of 12Z cells. CONCLUSION: . Its mechanism of action may involve the regulation of the TGF-β/ERK signaling pathway, leading to the inhibition of fibrosis in endometriosis.
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- europepmc
- last seen: 2026-06-04T01:30:01.192114+00:00
- openalex
- last seen: 2026-06-04T00:00:01.174412+00:00
- pubmed
- last seen: 2026-05-29T00:33:36.739615+00:00
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