Endometrial polyps affect uterine receptivity

Beth W. Rackow, Rackow BW, Elisa Jorgensen, Elisa M. Jorgensen, Jorgensen E, Hugh S. Taylor
Fertility and sterility · 2011 · vol. 95(8) , pp. 2690–2 · doi:10.1016/j.fertnstert.2010.12.034 · PMID:21269620 · PMC3096716
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This case-control study found that endometrial polyps significantly decrease HOXA10 and HOXA11 mRNA levels, providing a molecular mechanism for impaired uterine receptivity and reduced implantation rates.

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Abstract

This case-control study evaluated the effect of hysteroscopically identified endometrial polyps on endometrium by means of HOXA10 and HOXA11, known molecular markers of endometrial receptivity. Uteri with endometrial polyps demonstrated a marked decrease in HOXA10 and HOXA11 messenger RNA levels, which may impair implantation. These findings suggest a molecular mechanism to support the clinical findings of diminished pregnancy rates in women with endometrial polyps.

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MeSH descriptors

Embryo Implantation Embryo Implantation Fertility Fertility Infertility, Female Polyps Uterine Diseases Uterus Adult Case-Control Studies Connecticut Down-Regulation Female Genetic Markers Homeobox A10 Proteins Homeodomain Proteins Homeodomain Proteins Humans Hysteroscopy Infertility, Female

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europepmc
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pubmed
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