Antagonism of estrogen-induced lordosis by corticosterone in adrenalectomized-ovariectomized female rats and mice

D deCatanzaro, Denys deCatanzaro, Randolph P. Knipping, R P Knipping, B B Gorzalka, Boris B. Gorzalka
Pharmacology, biochemistry, and behavior · 1981 · vol. 15(5) , pp. 761–766 · doi:10.1016/0091-3057(81)90019-8 · PMID:7312911 · W1998105312
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Corticosterone administration antagonized estrogen-induced lordosis behavior in both female rats and mice that had undergone adrenalectomy and ovariectomy.

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Abstract

Previous experimentation has established that adrenalectomy can facilitate lordosis in ovariectomized estrogen-primed female rats. Experiment 1 examined the role of adrenal steroids in this effect, the results indicating an attenuation with chronic corticosterone but not with desoxycorticosterone or progesterone administration. Experiment 2 established a dose-response curve for this corticosterone effect. Experiments 3 and 4 indicated that corticosterone administration inhibits lordosis when it precedes estrogen administration. Experiment 5 demonstrated that corticosterone also inhibits estrogen-induced lordosis in mice. These data suggest that corticosterone may modulate estrogen-mediated behavior in rodents.

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MeSH descriptors

Corticosterone Estrogen Antagonists Sexual Behavior, Animal Adrenalectomy Animals Castration Corticosterone Estradiol Estradiol Female Mice Rats Rats, Inbred Strains Sexual Behavior, Animal Species Specificity Time Factors

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