The role of inflammatory cytokines in Meigs' syndrome

Yoram Abramov, Shaoul O Anteby, Sozos J. Fasouliotis, Vivian Barak
Obstetrics & Gynecology · 2002 · vol. 99(5) , pp. 917–919 · doi:10.1016/s0029-7844(01)01602-7 · PMID:11975958 · W2038858250
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Analysis of fluids from a Meigs' syndrome patient revealed elevated inflammatory cytokines that declined after tumor removal, suggesting these mediators contribute to the disorder's ascites and hydrothorax.

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Abstract

BACKGROUND: Inflammatory cytokines are known to induce capillary leakage and third-space fluid accumulation in numerous gynecologic and nongynecologic disorders. This study aimed to assess their role in Meigs' syndrome. CASE: Evaluation of serum, peritoneal, and pleural fluids retrieved from a patient suffering from Meigs' syndrome revealed high interleukin (IL)-1beta, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha levels. After surgical removal of the ovarian tumor and with resolution of ascites and hydrothorax, serum levels of IL-1beta, IL-6, and IL-8 declined, whereas tumor necrosis factor-alpha levels remained high. CONCLUSION: The correlation between these inflammatory cytokines and the clinical course of Meigs' syndrome suggests their involvement in the formation of ascites and hydrothorax in this disorder.

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MeSH descriptors

Cytokines Meigs Syndrome Cytokines Female Humans Interleukin-1 Interleukin-1 Interleukin-6 Interleukin-6 Interleukin-8 Interleukin-8 Meigs Syndrome Meigs Syndrome Postmenopause Tumor Necrosis Factor-alpha Tumor Necrosis Factor-alpha

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