Effects of hormone replacement therapy on depressive and anxiety symptoms after oophorectomy.

Danijela Đoković, Jelena Jović, Jelena D Ðoković, Marinela Knežević, Aleksandar Djukić, Dragana Ignjatović Ristić
In: Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina · 2015 · vol. 12(1) , pp. 79–85 · PMID:25669342 · W2412185470
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Estrogen-androgen replacement therapy significantly reduced depressive and anxiety symptoms in women who underwent oophorectomy compared to a control group.

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This observational prospective study evaluated whether estrogen-androgen hormone replacement therapy affects depressive and anxiety symptoms after bilateral oophorectomy in 80 women aged 35–45, compared with a perimenopausal control group aged 45–55 who were interviewed once. Depression and anxiety severity were measured using the Hamilton Depression Rating Scale and Hamilton Anxiety Rating Scale immediately after surgery and again at one, two, and three months in the treated group. The authors found that women who had undergone surgery had higher baseline depression and anxiety scores than controls, and that hormone therapy was associated with significant reductions in both depressive and anxiety symptoms over time, with depression differing significantly by one month and anxiety by three months; serum luteinizing hormone levels correlated with symptom scores. A key limitation is the nonrandomized design and the control group’s single time point. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

AIM: To assess the effect of hormone replacement therapy on postoperative depression and anxiety symptoms. METHODS: In observational prospective study 80 women divided into two groups were evaluated: women who received estrogen and androgen replacement therapy after hysterectomy with bilateral oophorectomy before onset of menopause (35-45 years old) and a control group that consisted of perimenipausal women (45-55 years old). Hormone replacement therapy began one week after surgery. The severity of depression and anxiety was evaluated through the use of Hamilton Depression Rating Scale and Hamilton Anxiety Rating Scale. Subjects from the study group were interviewed right after the surgical treatment, one, two and three months later. Subjects from the control group were interviewed only once. RESULTS: The women who underwent surgery had a statistically significantly higher score in Hamilton Depression Scale (p les than 0.001) and Hamilton Anxiety Scale (p=0.002) compared to the control perimenopausal women. There was a significant reduction of depressive and anxiety symptoms during hormone replacement therapy. Statistically significant difference in depressive score was found immediately after one month of hormone replacement therapy (first week/one month later: p=0.0057). Statistically significant difference in anxiety score appeared three months after the introduction of hormone therapy (first week/one month later: p=0.309; first week/two months later: p=0.046; first week/three months later: p les than 0.001). Level of serum luteinizing hormone was in correlation with depressive and anxiety score. CONCLUSION: Estrogen-androgen replacement therapy may reduce the risk of psychiatric disorders developing in women with bilateral oophorectomy (indication for hysterectomy with oophorectomy was leiomyomata uteri).
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Medicinski Glasnik (Feb 2015) Effects of hormone replacement therapy on depressive and anxiety symptoms after oophorectomy Abstract Aim To assess the effect of hormone replacement therapy on postoperative depression and anxiety symptoms. Methods In observational prospective study 80 women divided into two groups were evaluated: women who received estrogen and androgen replacement therapy after hysterectomy with bilateral oophorectomy before onset of menopause (35-45 years old) and a control group that consisted of perimenipausal women (45-55 years old). Hormone replacement therapy began one week after surgery. The severity of depression and anxiety was evaluated through the use of Hamilton Depression Rating Scale and Hamilton Anxiety Rating Scale. Subjects from the study group were interviewed right after the surgical treatment, one, two and three months later. Subjects from the control group were interviewed only once. Results The women who underwent surgery had a statistically significantly higher score in Hamilton Depression Scale (p<0.001) and Hamilton Anxiety Scale (p=0.002) compared to the control perimenopausal women. There was a significant reduction of depressive and anxiety symptoms during hormone replacement therapy. Statistically significant difference in depressive score was found immediately after one month of hormone replacement therapy (first week/one month later: p=0.0057). Statistically significant difference in anxiety score appeared three months after the introduction of hormone therapy (first week/one month later: p=0.309; first week/two months later: p=0.046; first week/three months later: p<0.001). Level of serum luteinizing hormone was in correlation with depressive and anxiety score. Conclusion Estrogen-androgen replacement therapy may reduce the risk of psychiatric disorders developing in women with bilateral oophorectomy (indication for hysterectomy with oophorectomy was leiomyomata uteri).

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