Correlations between periovulatory serum and follicular fluid CA-125 and granulosa cell hormones after controlled ovarian hyperstimulation

V K Saraf; Vishakh Saraf; Margaret O’Neill; M O'Neill; Anthony Riccioli; A Riccioli; P D Penha; Pedro Daniel Penha; Michael Femi Obasaju; M F Obasaju; John B. Josimovich; J B Josimovich

doi:10.1016/0301-2115(95)02168-7

Correlations between periovulatory serum and follicular fluid CA-125 and granulosa cell hormones after controlled ovarian hyperstimulation

V K Saraf, Vishakh Saraf, Margaret O’Neill, M O'Neill, Anthony Riccioli, A Riccioli, P D Penha, Pedro Daniel Penha, Michael Femi Obasaju, M F Obasaju, John B. Josimovich, J B Josimovich

European Journal of Obstetrics & Gynecology and Reproductive Biology · 1995 · vol. 62(1) , pp. 95–99 · doi:10.1016/0301-2115(95)02168-7 · PMID:7493717 · W2004627822

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This study investigated the relationship between CA-125 levels in serum and follicular fluid and granulosa cell hormones during controlled ovarian hyperstimulation.

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Abstract

OBJECTIVE: To determine the presence and concentration of CA-125 in periovulatory follicular fluid (FF) and serum after controlled ovarian hyperstimulation and to determine if the CA-125 in these two compartments could be related to granulosa cell markers such as inhibin or estradiol. STUDY DESIGN: Fifteen women undergoing controlled ovarian hyperstimulation for in-vitro fertilization-embryo transfer were studied. A transvaginal, ultrasound-guided follicular aspiration was performed. CA-125, inhibin, estradiol and FSH were measured in FF and serum. Pearson and Spearman's Rank Correlation tests were performed. RESULTS: CA-125 was measurable in 59% of follicles. Values ranged from undetectable to 3630 U/ml. Serum CA-125 ranged from undetectable to 126 U/ml. CA-125 and inhibin correlated negatively in FF and positively in serum. CONCLUSION: CA-125 was present in significant but variable concentrations in 59% of periovulatory follicles. A negative correlation was noted between CA-125 and inhibin or estradiol in the FF and a positive correlation with serum inhibin. No correlations were noted to oocyte retrieval or fertilization.

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MeSH descriptors

CA-125 Antigen Follicular Fluid Granulosa Cells Hormones Ovulation Ovulation Induction Adult CA-125 Antigen CA-125 Antigen Embryo Transfer Estradiol Estradiol Estradiol Female Fertilization in Vitro Follicle Stimulating Hormone Follicle Stimulating Hormone Follicle Stimulating Hormone Follicular Fluid Granulosa Cells

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Cites (2)

References (21)

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[1] Serum CA-125 antigen levels increase during menses 1987

[2] The CA 125 tumour-associated antigen: a review of the literature 1989