Promigratory and proangiogenic effects of AdipoRon on bone marrow-derived mesenchymal stem cells: an in vitro study

Sara Malih, Malih S, Massoud Saidijam, Mansouri K, Kamran Mansouri, Pourjafar M, Mona Pourjafar, Tafakh MS, Maryam Sadat Tafakh, Talebzadeh F, Fahimeh Talebzadeh, Rezvan Najafi
Biotechnology letters · 2017 · vol. 39(1) , pp. 39–44 · doi:10.1007/s10529-016-2214-0 · PMID:27627895
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AdipoRon preconditioning enhances rat bone marrow-derived mesenchymal stem cell survival, migration, and angiogenesis by upregulating COX-2, HIF-1, CXCR4, CCR2, MMP-2, and MMP-9 expression.

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Abstract

OBJECTIVES: To investigate the effect of AdipoRon on major factors involved in survival, migration and neovascularization of rat bone marrow-derived mesenchymal stem cells. RESULTS: AdipoRon promoted the MSCs viability. Real-time PCR indicated that the expression of cyclooxygenase-2 (COX-2), hypoxia-inducible factor-1 (HIF-1) C-X-C chemokine receptor type 4 (CXCR4), C-C chemokine receptor type 2 (CCR2), vascular endothelial growth factor matrix metalloproteinase-2 (MMP-2) and MMP-9 were upregulated in AdipoRon-treated MSCs compared to control groups. Prostaglandin E2 (PGE2) level, as well as migration ability of MSCs (scratch assay) was enhanced by AdipoRon preconditioning. CONCLUSION: Preconditioning of MSCs with AdipoRon prior to transplantation could enhance cell survival, angiogenesis and migration via activating the COX-2/PGE2/HIF-1 pathway and other contributing factors.

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MeSH descriptors

Bone Marrow Cells Mesenchymal Stem Cells Mesenchymal Stem Cells Piperidines Animals Bone Marrow Cells Cells, Cultured Hypoxia-Inducible Factor 1, alpha Subunit Hypoxia-Inducible Factor 1, alpha Subunit Male Matrix Metalloproteinase 2 Matrix Metalloproteinase 2 Matrix Metalloproteinase 9 Matrix Metalloproteinase 9 Mesenchymal Stem Cells Mesenchymal Stem Cells Piperidines Rats Rats, Wistar Receptors, CCR2

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europepmc
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