Interleukin-1beta regulates vascular endothelial growth factor and soluble fms-like tyrosine kinase-1 secretion by human oviductal epithelial cells and stromal fibroblasts

Kaei Nasu, Hiroko Itoh, Akitoshi Yuge, Yasushi Kawano, Jun Yoshimatsu, Hisashi Narahara
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2006 · vol. 22(9) , pp. 495–500 · doi:10.1080/08916930600929487 · PMID:17071533 · W2016405545
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Interleukin-1β stimulates vascular endothelial growth factor and soluble fms-like tyrosine kinase-1 secretion by human oviductal epithelial cells and stromal fibroblasts, with IL-1RA inhibiting this response.

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Abstract

The aim of the present study was to evaluate the effects of interleukin (IL)-1beta on the production of vascular endothelial growth factor (VEGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) in the human fallopian tube. Human oviductal epithelial cells (OECs) and oviductal stromal fibroblasts (OSFs) were isolated from ten premenopausal patients. The secretion of VEGF and sFlt-1 by cultured OECs and OSFs in response to IL-1beta and IL-1 receptor antagonist (IL-1RA) was measured using an enzyme-linked immunosorbent assay. The secretion of VEGF and sFlt-1 was detected in cultured OECs and OSFs under untreated conditions; secretion of these angiogenic modulators was significantly stimulated with IL-1beta administration in these cells. IL-1beta-induced production of VEGF and sFlt-1 by these cells was significantly inhibited by the addition of IL-1RA. The present findings suggest that IL-1beta in the local environment may stimulate oviductal vascular permeability by inducing the production of VEGF by oviductal cells via both autocrine and paracrine mechanisms. Simultaneous upregulation of sFlt-1 secretion by these cells after IL-1beta stimulation may prevent an excessive upregulation of vascular permeability. The modulation of the ratio of VEGF and sFlt-1 in the fallopian tube may contribute to the normal and pathological processes of oviductal fluid secretion by regulating oviductal vascular permeability during the menstrual cycle and during the peri-implantation period.

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MeSH descriptors

Epithelial Cells Epithelial Cells Interleukin-1beta Oviducts Oviducts Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor Receptor-1 Adult Animals Cells, Cultured Epithelial Cells Female Fibroblasts Humans Interleukin-1beta Oviducts Receptors, Interleukin-1 Receptors, Interleukin-1 Receptors, Interleukin-1 Solubility

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