Profiling of peritoneal fluid of women with endometriosis by chemokine protein array.

Piotr Laudański, P Laudański, Jacek Szamatowicz, J Szamatowicz, M Oniszczuk
Advances in medical sciences · 2006 · vol. 51 , pp. 148–52 · PMID:17357296 · W2165292543
article OA: closed CC0 ⤵ 24 in-corpus citations
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This study used a chemokine protein array to find significantly higher MIP-3beta/CCL19 concentrations in peritoneal fluid of women with endometriosis compared to controls.

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Abstract

PURPOSE: Chemokines play essential role not only in controlling leukocyte function and trafficking but also in the angiogenesis and modulation of inflammatory responses. MATERIAL AND METHODS: A novel array-based enzyme-linked immunosorbent assay was used to quantitate peritoneal fluid chemokines of 25 infertile women with endometriosis and 18 controls. For our preliminary studies we chose mini-array containing nine different chemokines: MDC/CCL22, TARC/CCL17, MCP-1/CCL2, RANTES/CCL5, MIP-1alpha/CCL3, -1beta/CCL4, -1delta/CCL15, -3alpha/CCL20, and -3beta/CCL19. RESULTS: We found significantly higher MIP-3beta/CCL19 (P = 0.0036) concentrations in peritoneal fluid of women with endometriosis as compared to patients with primary infertility without any signs of disease. CONCLUSIONS: Our preliminary results suggest that MIP-3beta/ /CCL19 might play a role in the pathogenesis of endometriosis but its precise role remains to be established. Novel types of screening methods based on high-throughput technologies offer great opportunities to study immunobiology of endometriosis. It will hopefully provide new possibilities for discovery of new markers and potential drug targets.

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Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

Ascitic Fluid Chemokines Endometriosis Adult Ascitic Fluid Chemokines Endometriosis Endometriosis Enzyme-Linked Immunosorbent Assay Enzyme-Linked Immunosorbent Assay Female Humans Infertility, Female Infertility, Female Infertility, Female

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (24)

Cited by (24)

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