The analysis of the prevalence of extragenital pathology in infertile women with external genital endometriosis

S. V. Zotov, P. Yu. Motyreva, A.V. Volchek, V. V. Likhacheva, O. V. Azarova, B. I. Ayzikovich
In: Acta Biomedica Scientifica · 2022 · vol. 7(2) , pp. 24–33 · doi:10.29413/abs.2022-7.2.3 · W4281570307
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This study identified bowel diseases, cardiac maldevelopments, chronic anemia, pancreatic pathology, chronic tonsillitis, and allergies as extragenital diseases frequently associated with external genital endometriosis in infertile women.

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The paper analyzed clinical and anamnestic data from 1132 infertile women of reproductive age evaluated at a fertility clinic between 2019 and 2021, with diagnosis of external genital endometriosis (verified by laparoscopy and histology) and statistical modeling (exact criterion and binary logistic regression) to assess associations with comorbid somatic conditions. External genital endometriosis was found in 222 women, and the study reported that several extragenital/extragenital-type diseases were more frequent, including intestinal diseases, minor cardiac developmental anomalies, chronic anemia, pancreatic pathology, chronic tonsillitis, and allergy. A logistic regression model was built to predict external genital endometriosis presence among women with the specified somatic conditions, reporting sensitivity of 81.53% and specificity of 97.25%. The paper proposes that recognizing such comorbidities in infertile women could justify expanding the extent of diagnostic and treatment measures, including laparoscopy, though it does not describe other limitations such as causal direction. This paper is centrally about endometriosis — it specifically examines the prevalence and predictive association of extragenital comorbid pathology in infertile women with external genital endometriosis.

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Abstract

Background. External genital endometriosis (EGE) is often the cause of infertility, while coagulation of its foci leads to the restoration of fertility. Often, non-invasive preoperative diagnosis of EGE is difficult. Today, the issue of laparoscopy in infertility and whether there is a need for additional indications for its implementation remains controversial. Identification of the relationship between certain extragenital diseases with EGE is promising in terms of both understanding the pathogenesis of EGE and predicting its development. The aim. Identification of the relationship of extragenital diseases with the presence of EGE in infertile women of reproductive age. Materials and methods. In preparation for assisted reproductive technology programs at the Vitromed Clinic, 1 132 women of reproductive age were examined from 2019 to 2021. Collection and processing of clinical and anamnestic data were carried out. The diagnosis of EGE was verified by laparoscopy with histological examination. The results were analyzed using exact test and binary logistic regression to build a model of the relationship between EGE and somatic pathology. Results. EGE was detected in 222 patients. A number of somatic diseases were found that are most common in EGE: bowel diseases; minor cardiac maldevelopments; chronic anemia; pathology of the pancreas; chronic tonsillitis; allergy. A logistic regression model was constructed to predict the presence of EGE in patients with the indicated somatic pathology with a sensitivity of 81.53 % and a specificity of 97.25 %. Conclusion. Identification of comorbid extragenital diseases associated with EGE in women with infertility can serve as a basis for expanding the scope of therapeutic and diagnostic measures, in particular for laparoscopy.
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Анализ распространённости экстрагенитальной патологии у инфертильных женщин с наружным генитальным эндометриозом https://doi.org/10.29413/ABS.2022-7.2.3 Аннотация Актуальность. Наружный генитальный эндометриоз (НГЭ) нередко является причиной бесплодия, при этом коагуляция его очагов приводит к восстановлению фертильности. Зачастую неинвазивная дооперационная диагностика НГЭ затруднена. Сегодня спорным остаётся вопрос о проведении лапароскопии при бесплодии и о том, существует ли необходимость в дополнительных показаниях к её выполнению. Выявление взаимосвязи между определёнными экстрагенитальными заболеваниями с НГЭ является перспективным относительно как понимания патогенеза НГЭ, так и прогнозирования его развития. Цель исследования. Выявление взаимосвязи экстрагенитальных заболеваний с наличием НГЭ у инфертильных женщин репродуктивного возраста. Материалы и методы исследования. При подготовке к программам вспомогательных репродуктивных технологий в клинике «Витромед» с 2019 по 2021 г. обследованы 1132 женщины репродуктивного возраста. Проводились сбор и обработка клинико-анамнестических данных. Диагноз НГЭ верифицировали посредством лапароскопии с гистологическим исследованием. Результаты анализировали с использованием точного критерия и бинарной логистической регрессии для построения модели взаимосвязи НГЭ и соматической патологии. Результаты исследования. НГЭ выявлен у 222 пациенток. Обнаружен ряд соматических заболеваний, наиболее часто встречающихся при НГЭ: заболевания кишечника; малые аномалии развития сердца; хроническая анемия; патология поджелудочной железы; хронический тонзиллит; аллергия. Построена логистическая регрессионная модель, позволяющая прогнозировать наличие НГЭ у пациенток с указанной соматической патологией с чувствительностью 81,53 % и специфичностью 97,25 %. Заключение. Выявление у женщин с бесплодием коморбидных экстрагенитальных заболеваний, сопутствующих НГЭ, может служить основанием для расширения объёма лечебно-диагностических мероприятий, в частности для лапароскопии. Ключевые слова Об авторах С. В. ЗотовРоссия заведующий отделением репродуктологии 630008, г. Новосибирск, ул. Сакко и Ванцетти, 77 П. Ю. Мотырева Россия старший биолог 630099, г. Новосибирск, ул. Коммунистическая, 17 А. В. Волчек Россия врач акушер-гинеколог 630087, г. Новосибирск, ул. Немировича-Данченко, 130 В. В. Лихачева Россия доктор медицинских наук, доцент кафедры акушерства и гинекологии 654005, г. Новокузнецк, ул. Строителей, 5 О. В. Азарова Россия доктор медицинских наук, врач акушер-гинеколог, репродуктолог 654041, г. Новокузнецк, ул. Кутузова, 17а Б. И. Айзикович Россия доктор медицинских наук, доцент, профессор кафедры фундаментальной медицины Института медицины и психологии В. Зельмана 630090, г. Новосибирск, ул. Пирогова, 1 Список литературы 1. Wyns C, Bergh C, Calhaz-Jorge C, De Geyter C, Kupka MS, Motrenko T, et al.; European IVF-monitoring Consortium (EIM) for the European Society of Human Reproduction and mbryology (ESHRE). ART in Europe. 2016: Results generated from European registries by ESHRE. Hum Reprod Open. 2020; 31(3): 1957-1973. doi: 10.1093/hropen/hoaa032 2. Mikhaleva LM, Radzinsky VE, Orazov MR, Khovanskaya TN, Sorokina AV, Mikhalev SA, et al. Current knowledge on endometriosis etiology: A systematic review of literature. Int J Womens Health. 2021; 1(13): 525-537. doi: 10.2147/IJWH.S306135 3. Оразов М.Р., Духин А.О., Шкрели И., Бикмаева Я.Р. Структура соматической патологии женщин с рецидивирующим овариальным эндометриозом. Research’n Practical Medicine Journal. 2016; 3(Спецвыпуск): 122-123. 4. Matalliotaki C, Matalliotakis M, Zervou MI, Trivli A, Matalliotakis I, Mavromatidis G, et al. Co-existence of endometriosis with 13 non-gynecological co-morbidities: Mutation analysis by whole exome sequencing. Mol Med Rep. 2018; 18(6): 5053-5057. doi: 10.3892/mmr.2018.9521 5. Shigesi N, Kvaskoff M, Kirtley S, Feng Q, Fang H, Knight JC, et al. The association between endometriosis and autoimmune diseases: A systematic review and metaanalysis. Hum Reprod Update. 2019; 25(4): 486-503. doi: 10.1093/humupd/dmz014 6. Asghari S, Valizadeh A, Aghebati-Maleki L, Nouri M, Yousefi M. Endometriosis: Perspective, lights, and shadows of etiology. Biomed Pharmacother. 2018; 106: 163-174. doi: 10.1016/j.biopha.2018.06.109 7. Токаева Э.С., Оразов М.Р., Барсегян Л.К. Особенности коморбидного статуса у пациенток с эндометриоз-ассоциированной тазовой болью. Хирургическая практика. 2016; (3): 24-26. 8. Kvaskoff M, Mu F, Terry KL, Harris HR, Poole EM, Farland L, et al. Endometriosis: A high-risk population for major chronic diseases? Hum Reprod Update. 2015; 21(4): 500-516. doi: 10.1093/humupd/dmv013 9. Scarselli G, Rizzello F, Cammilli F, Ginocchini L, Coccia ME. Diagnosis and treatment of endometriosis. A review. Minerva Ginecol. 2005; 57(1): 55-78. 10. Bazot M, Daraï E. Diagnosis of deep endometriosis: Clinical examination, ultrasonography, magnetic resonance imaging, and other techniques. Fertil Steril. 2017; 108(6): 886-894. doi: 10.1016/j.fertnstert.2017.10.026 11. Practice Committee of the American Society for Reproductive Medicine. Treatment of pelvic pain associated with endometriosis: A committee opinion. Fertil Steril. 2014; 101(4): 927-935. doi: 10.1016/j.fertnstert.2014.02.012 12. Barra F, Scala C, Biscaldi E, Vellone VG, Ceccaroni M, Terrone C, et al. Ureteral endometriosis: A systematic review of epidemiology, pathogenesis, diagnosis, treatment, risk of malignant transformation and fertility. Hum Reprod Update. 2018; 24(6): 710-730. doi: 10.1093/humupd/dmy027 13. Kiesel L, Sourouni M. Diagnosis of endometriosis in the 21st century. Climacteric. 2019; 22(3): 296-302. doi: 10.1080/13697137.2019.1578743 14. Nisenblat V, Bossuyt PM, Shaikh R, Farquhar C, Jordan V, Scheffers CS, et al. Blood biomarkers for the non-invasive diagnosis of endometriosis. Cochrane Database Syst Rev. 2016; 2016(5): CD012179. doi: 10.1002/14651858.CD012179 15. Nisenblat V, Prentice L, Bossuyt PM, Farquhar C, Hull ML, Johnson N. Combination of the non-invasive tests for the diagnosis of endometriosis. Cochrane Database Syst Rev. 2016; 7(7): CD012281. doi: 10.1002/14651858.CD012281 16. Hudson QJ, Perricos A, Wenzl R, Yotova I. Challenges in uncovering non-invasive biomarkers of endometriosis. Exp Biol Med (Maywood). 2020; 245(5): 437-447. doi: 10.1177/1535370220903270 17. Nezhat C, Li A, Falik R, Copeland D, Razavi G, Shakib A, et al. Bowel endometriosis: diagnosis and management. Am J Obstet Gynecol. 2018; 218(6): 549-562. doi: 10.1016/j.ajog.2017.09.023 18. Scioscia M, Orlandi S, Trivella G, Portuese A, Bettocchi S, Pontrelli G, et al. Sonographic differential diagnosis in deep infiltrating endometriosis: The bowel. Biomed Res Int. 2019; 2019: 5958402. doi: 10.1155/2019/5958402 19. Bazot M, Kermarrec E, Bendifallah S, Daraï E. MRI of intestinal endometriosis. Best Pract Res Clin Obstet Gynaecol. 2021; 71: 51-63. doi: 10.1016/j.bpobgyn.2020.05.013 20. Andres MP, Arcoverde FVL, Souza CCC, Fernandes LFC, Abrão MS, Kho RM. Extrapelvic endometriosis: A systematic review. J Minim Invasive Gynecol. 2020; 27(2): 373-389. doi: 10.1016/j.jmig.2019.10.004 21. Monrad-Hansen PW, Buanes T, Young VS, Langebrekke A, Qvigstad E. Endometriosis of the pancreas. J Minim Invasive Gynecol. 2012; 19(4): 521-523. doi: 10.1016/j.jmig.2012.03.011 22. Choi EJ, Cho SB, Lee SR, Lim YM, Jeong K, Moon HS, et al. Comorbidity of gynecological and non-gynecological diseases with adenomyosis and endometriosis. Obstet Gynecol Sci. 2017; 60(6): 579-586. doi: 10.5468/ogs.2017.60.6.579 23. Земцовский Э.В., Малев Э.Г., Лобанов М.Ю., Парфенова Н.Н., Реева С.В., Хасанова С.И., и др. Малые аномалии сердца. Российский кардиологический журнал. 2012; 1(93): 77-81. 24. Redwine DB. Mülleriosis instead of endometriosis. Am J Obstet Gynecol. 1987; 156(3): 761. doi: 10.1016/0002-9378(87)90093-7 25. Gemmill JA, Stratton P, Cleary SD, Ballweg ML, Sinaii N. Cancers, infectins, and endocrine diseases in women with endometriosis. Fertil Steril. 2010; 94(5): 1627-1631. doi: 10.1016/j.fertnstert.2009.07.1698 Рецензия Для цитирования: Зотов С.В., Мотырева П.Ю., Волчек А.В., Лихачева В.В., Азарова О.В., Айзикович Б.И. Анализ распространённости экстрагенитальной патологии у инфертильных женщин с наружным генитальным эндометриозом. Acta Biomedica Scientifica. 2022;7(2):24-33. https://doi.org/10.29413/ABS.2022-7.2.3 For citation: Zotov S.V., Motyreva P.Yu., Volchek A.V., Likhacheva V.V., Azarova O.V., Ayzikovich B.I. The analysis of the prevalence of extragenital pathology in infertile women with external genital endometriosis. Acta Biomedica Scientifica. 2022;7(2):24-33. (In Russ.) https://doi.org/10.29413/ABS.2022-7.2.3 JATS XML

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