Transforming growth factor-β1 and insulin-like growth factor-1 expression in ovarian endometriotic cysts: a preliminary study
This study found increased TGF-beta 1 mRNA and stromal expression, along with disregulated IGF-1 and its receptor, in ovarian endometriotic tissues, suggesting their involvement in endometriosis pathogenesis.
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This preliminary study examined TGF-β1 and IGF-1 expression and localization, including IGF-1 receptor, in ovarian endometriotic tissues obtained during surgery, using Northern hybridization for steady-state mRNA levels and immunohistochemistry for protein localization. The authors found comparable IGF-1 and IGF-1 receptor expression in the stromal and epithelial compartments, supporting disregulated expression of the IGF system in ovarian endometriosis, while TGF-β1 mRNA was strongly increased in all endometriotic samples. Immunohistochemistry showed weak TGF-β1 staining in the epithelial lining and intense expression in the cellular stroma of ovarian endometriomas, suggesting a role in disease maintenance and propagation. This paper is centrally about endometriosis — it focuses on TGF-β1 and IGF-1 expression in ovarian endometriotic cysts.
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Cited by (28)
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- Reduced cardiovascular risks in women with endometriosis or polycystic ovary syndrome carrying a common functional<i>IGF1R</i>variant 2022
- Immunopathogenesis of endometriosis: An overview of the role of innate and adaptive immune cells and their mediators 2022
- Endometriosis Stem Cells as a Possible Main Target for Carcinogenesis of Endometriosis-Associated Ovarian Cancer (EAOC) 2022
- P1 promoter IGF-1 polymorphism and IGF-1, IGF-R, LSF, and TSG 101 expression profile in endometriosis 2021
- Circulating miRNAs Related to Epithelial–Mesenchymal Transitions (EMT) as the New Molecular Markers in Endometriosis 2021
- Targeted inhibition of TAK1 abrogates TGFβ1 non-canonical signaling axis, NFκB/Smad7 inhibiting human endometriotic cells proliferation and inducing cell death involving autophagy 2021
- Malignant Transformation and Associated Biomarkers of Ovarian Endometriosis: A Narrative Review 2020
- Focal Adhesion Kinase-Mediated Sequences, Including Cell Adhesion, Inflammatory Response, and Fibrosis, as a Therapeutic Target in Endometriosis 2020
- A high level of TGF-B1 promotes endometriosis development via cell migration, adhesiveness, colonization, and invasiveness† 2018
- Cancer driver mutations in endometriosis: Variations on the major theme of fibrogenesis 2018
- Epithelial-to-mesenchymal transition in the development of endometriosis 2017
- Innovative approach in assessing the role of neurogenesis, angiogenesis, and lymphangiogenesis in the pathogenesis of external genital endometriosis 2016
- Seminal Plasma Promotes Lesion Development in a Xenograft Model of Endometriosis 2015
- The Role of the Lymphatic System in Endometriosis: A Comprehensive Review of the Literature1 2015
- The effect of macrophages on fibroblast activity and lesion development in mouse models of endometriosis. 2014
- Expression and role of peptides, proteins and growth factors in the pathogenesis of endometriosis 2009
- Induction of endometrial epithelial cell invasion and c-fms expression by transforming growth factor beta 2009
- Endometriosis and ovarian reserve : Inflammation and prognostic markers 2008
- Decreased human leukocyte antigen–DR expression in the lipid raft by peritoneal macrophages from women with endometriosis 2007
- Effect of recombinant human TNF–binding protein-1 and GnRH antagonist on mRNA expression of inflammatory cytokines and adhesion and growth factors in endometrium and endometriosis tissues in baboons 2007
- Polymorphism for Transforming Growth Factor Beta 1-509 (TGF-B1-509): Association with Endometriosis 2005
- Human leukocyte antigen expression by peritoneal macrophages from women with pelvic endometriosis is depressed but coordinated with costimulatory molecule expression 2005
- Endometriotic Cells Exhibit Metaplastic Change and Oxidative DNA Damage as Well as Decreased Function, Compared to Normal Endometrium 2005
- Insulin-like growth factor II gene Apa I polymorphism is not associated with endometriosis susceptibility 2004
- The Role of Cytokines in Endometriosis* 2003
- Coordinated but depressed expression of human leukocyte antigen-DR, intercellular adhesion molecule-1, and CD14 on peritoneal macrophages in women with pelvic endometriosis 2003
- Spatially Heterogenous Expression of Aromatase P450 through Promoter II Is Closely Correlated with the Level of Steroidogenic Factor-1 Transcript in Endometrioma Tissues 2002
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