Alterations in lipid metabolism in ovarian endometriosis and combined ovarian cancer revealed by untargeted lipidomics

YuHan DUAN, HeLin WANG, Kun ZHANG
2025 · doi:10.1360/ssv-2024-0352 · W7083673460
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Untargeted lipidomics revealed distinct lipid metabolism differences in serum and urine between ovarian endometriosis, benign ovarian tumors, and ovarian cancer, suggesting a role for lipid metabolism in endometriosis and its progression to cancer.

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Abstract

目的：分析比较卵巢子宫内膜异位症（ovarian endometriosis，OEMs）与卵巢良性肿瘤（benign ovarian tumor，BOT）和OEMs合并卵巢癌（Ovarian cancer，OC）患者血清及尿液中脂质代谢产物的差异及相关代谢途径，初步探究与OEMs发生及其恶化相关的脂质成分，进一步深入了解EMs的发生发展机制。 方法：选择10名患有OEMs(对照组)、10名患有BOT（BOT组）和10名患有OEMs合并卵巢癌（恶性组）的育龄期妇女的血清及尿液样本。采用非靶向超高效液相色谱-质谱（UPLC-LC-MS）分析各组样本差异脂质代谢产物，通过多变量偏最小二乘判别分析（partial least squares discriminant analysis，PLS-DA）模型分析前两个主成分的计算变量投影重要度（Variable Important for the Projection，VIP）值，结合单变量分析变异倍数分析（Fold change）和 T 检验（p-value）值来筛选差异表达的代谢物，进一步通过KEGG注释筛选相关代谢途径。 结果：经单变量与多变量联合统计分析，BOT组与对照组血清及尿液样本进行检测，两组研究对象血清及尿液脂质代谢物均存在显著差异，其中血清中有13种显著不同的脂质代谢物，尿液中有9种。KEGG结果注释分析显示花生四烯酸代途径在血清及尿液中均富集，自噬途径在血清样本中富集。恶性组与对照组血清及尿液脂质代谢物均存在显著差异，其中血清中有81种显著不同的脂质代谢物，尿液中有6种，血清和尿液样本均存在显著差异的脂质代谢物为主要有甘油磷脂酸（phosphatidic acid，PA）和磷脂酰胆碱（Phosphatidyl cholines，PC）。KEGG结果注释分析显示亚油酸代谢途径在血清及尿液中均富集，而血清样本中还揭示了鞘脂信号通路、花生四烯酸代谢途径的富集。 结论：本次OEMs合并卵巢癌患者及BOT患者相比单纯OEMs患者血清及尿液脂质代谢物表达均存在差异，提示了OEMs的发生及合并卵巢癌与脂质代谢可能有关。
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endometriosis

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