Early menarche in Japanese Down syndrome

Takako Takano, T Takano, Haruyoshi Takaki, H Takaki, H Kawano, Hatsuko Kawano, K Nonaka, Koichi Nonaka
Pediatrics · 1999 · vol. 103(4) , pp. 854 · doi:10.1542/peds.103.4.854 · PMID:10206857 · W2021839613
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This study found that the mean age of menarche was 12.1 years in 60 menstruating Japanese girls with Down syndrome, which is significantly earlier than the 12.5 years observed in recent Japanese women without the condition.

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Abstract

To the Editor. We obtained information on 95 female patients (age 9–18 years) with Down syndrome in Japan. The period of their birth was between 1976 and 1984 (median 1980). The mean menarcheal age of 60 menstruating subjects was 12.1 ± 1.2 (SD) (Table 1). It was earlier than that of recent Japanese women (12.5 ± 1.0, N = 1,161 birth year 1974–19791) ( P < .05). View this table: Table 1. Early Menarche in Down …

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MeSH descriptors

Down Syndrome Menarche Menarche Age Factors Child Down Syndrome Down Syndrome Female Humans Japan Obesity Obesity Obesity

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