Eicosanoids, menstruation and menstrual disorders

One of the most exciting recent developments in the understanding of endometrial and myometrial function has been the realization that a range of eicosanoids are synthesized within and have major biological actions on uterine tissues. Evidence is rapidly accumulating to indicate that eicosanoids are responsible for a wide range of physiological uterine functions and pathological disturbances. This is particularly exemplified by their involvement in menstruation and several menstrual disorders. Preview Unable to display preview. Download preview PDF. Similar content being viewed by others

Leaver, H.A. and Poyser, N.L. (1983). Arachidonic acid in guinea-pig uterus and plasma. In Samuelsson, B., Ramwell, P.W. and Paoletti, R. (eds.) Advances in Prostaglandin and Thromboxane Research, 8, pp. 1361–1363 (New York: Raven Press) Pickles, V.R., Hall, W.J., Best, F.A. and Smith G.N. (1965). Prostaglandins in endometrium and menstrual fluid from normal and dysmenorrhoeic women. J. Obstet. Gynaecol. Br. Commonw., 72, 185–192 Downie, J., Poyser, N.L. and Wunderlich, N. (1974). Levels of prostaglandins in human endometrium during the normal menstrual cycle. J. Physiol, 236, 465–469 Singh, E.J., Baccarini, I.M. and Zuspan, F.P. (1975). Levels of prostaglandins F2α and E2 in human endometrium during the menstrual cycle. Am. J. Obstet. Gynecol., 121, 1003–1006 Gréen, K. and Hagenfeldt, K. (1975). Prostaglandins in the human endometrium. Gas chromatographic-mass spectrometric quantitation before and after IUD insertion. Am. J. Obstet. Gynecol, 122, 611–614 Jordan, V.C. and Pokoly, T.V. (1977). Steroid and prostaglandin relations during the menstrual cycle. Obstet. Gynecol, 49, 449–453 Maathuis, J.V. and Kelly, R.W. (1978). Concentration of prostaglandins F2α and E2 in endometrium throughout the human menstrual cycle, after the administration of Clomiphene or an oestrogen/progestogen pill, and in early pregnancy. J. Endocrinol, 77, 361–376 Liggins, G.C., Campos, G.A., Roberts, C.N. and Skinner, S.J. (1980). Production rates of prostaglandin F, 6-keto-PGFlα and thromboxane B2 by perifused human endometrium. Prostaglandins, 19, 461–477 Yamanoto, S., Ohki, S., Ogino, N., Shimizu, T., Yoshimoto, T., Watanabe, K. and Hayaishi, O. (1980). Enzymes involved in the formation and further transformations of prostaglandin endoperoxides. In Samuelsson, B., Ramwell, P.W. and Paoletti, R. (eds.) Advances in Prostaglandin and Thromboxane Research, pp. 27–33. (New York: Raven Press) Kelly, R.W. and Abel, M.H. (1980). Catechol oestrogens stimulate and direct prostaglandin synthesis. Prostaglandins, 20, 613–626 Abel, M.H. and Baird, D.T. (1980). The effect of 17-β oestradiol and progesterone on prostaglandin production by human endometrium maintained in organ culture. Endocrinology, 106, 1599–1605 Peek, M.J., Fraser, I.S., Phillips, C.A., Resta, T.M., Blackwell, P.M. and Markham, R. (1985). The measurement of human endometrial prostaglandin production: a comparison of two in vitro methods. Prostaglandins, 29, 3–18 Rees, M.C.P., Anderson, A.B.M., Demers, L.M. and Turnbull, A.C. (1984). Endometrial and myometrial prostaglandin release during the menstrual cycle in relation to menstrual blood loss. J. Clin. Endocrinol Metab., 58, 813–818 Abel, M.H. and Kelly, R.W. (1979). Differential production of prostaglandin within the human uterus. Prostaglandins, 18, 821–834 Rees, M.C.P. (1982). Uterine prostaglandins and menstrual blood loss. Res. Clin. Forums, 4, 19–22 Casey, M.L., Hensell, D.L., MacDonald, P.C. and Johnston, J.M. (1980). NAD + dependent 15-hydroxyprostaglandin dehydrogenase activity in human endometrium. Prostaglandins, 19, 115–127 Ghodgaonkar, R.V., Dubin, N.H. and Blake, D.A. (1979). 13, 14-dihydro-15-keto-prostaglandin F2α concentrations in human plasma and amniotic fluid. Am. J. Obstet. Gynecol, 134, 265–272 Koullapis, E.N. and Collins, W.P. (1980). The concentration of 13, 14-dihydro-15-oxoprostaglandin F2α in peripheral venous plasma throughout the normal ovarian and menstrual cycle. Acta Endocrinol, 93, 123–138 Thorburn, G.D., Cox, R.I, Currie, W.B., Restall, B.J. and Schneider, W. (1973). Prostaglandin F and progesterone concentrations in the utero-ovarian venous plasma of the ewe during the oestrus cycle and early pregnancy. J. Reprod. Fertil, Supplement 18, 151–158 Roberts, J.S., McCracken, J.A., Gavagan, J.E. and Soloff,M.S. (1976). Oxytocin stimulated release of prostaglandin F2α from ovine endometrium in vitro: correlation with oestrus cycle and oxytocin-receptor binding. Endocrinology., 99, 1107–1114 Saaed, S.A., Strickland, D.M., Young, D.C., Dang, A. and Mitchell, M.D. (1982). Inhibition of prostaglandin synthesis by human amniotic fluid: acute reduction in inhibitory activity of amniotic fluid obtained during labour. J. Clin. Endocrinol Metab., 55, 801–811 Healy, D.L. and Hodgen, G.D. (1983). The endocrinology of human endometrium. Obstet. Gynecol Survey, 38, 509–530 Chan, W.Y., Dawood, M.Y. and Fuchs, F. (1981). Prostaglandins in primary dysmenorrhoea: comparison of prophylactic and non-prophylactic treatment with Ibuprofen and use of oral contraceptives. Am. J. Med., 70, 535–539 Ylikorkala, O., Puolakka, J. and Viinikka, L. (1981). Oestrogen containing oral contraceptives decrease prostacyclin production. Lancet, 1, 42 Witter, F.R. and Di Blasi, M.C. (1984). Effect of steroid hormones on arachidonic acid metabolites of endothelial cells. Obstet. Gynecol., 63, 747–751 Saeed, S.A. and Mitchell, M.D. (1982). Formation of arachidonate lipoxygenase metabolites by human foetal membranes, uterine decidua vera and placenta. Prostagl, Leukotr. and Med., 8, 635–642 Demers, L.M., Rees, M.C.P. and Turnbull, A.C. (1984). The metabolism of arachidonic acid by the non-pregnant human uterus. Prostagl, Leukotr. and Med., 14, 175–181 Abel, M.H., Zhu, C. and Baird, D.T. (1982). An animal model to study menstrual bleeding. Res. Clin. Forums, 4, 25–34 Hofmann, G.E., Rao, C.V., De Leon, F.D., Toledo, A.A. and San Filippo, J.S. (1985). Human endometrial prostaglandin E2 binding sites and their profiles during the menstrual cycle and in pathologic states. Am. J. Obstet. Gynecol, 151, 269–375 Hofmann, G.E., Rao, C.V., Barrows, G.H. and San Fillipo, J.S. (1983). Topography of human uterine prostaglandin E and F2α receptors and their profiles during pathological states. J. Clin. Endocrinol Metab., 57, 360–368 Bygdeman, M. (1964). The effect of different prostaglandins on human myometrium in vitro.Acta Physiol Scand., 63, (supplement) 1–15 Wilhelmsson, L., Lindblom, D. and Wiqvist, N. (1979). The human utero-tubal junction: contractile patterns of different smooth muscle layers and the influence of prostaglandin E2, prostaglandin F2α and prostaglandin I2 in vitro. Fértil Steril, 32, 303–307 Wilhelmsson, L., Wikland, M. and Wiqvist, N. (1981). PGH2, TXA2and PGI2have potent and differentiated actions on human uterine contractility. Prostaglandins, 21, 277–286 Weichman, B.M. and Tucker, S.S. (1982). Contraction of the guinea pig uterus by synthetic leukotrienes. Prostaglandins, 24, 245–256 Carraher, R., Hahn, D.W., Ritchie, D.M. and McGuire, J.L. (1983). Involvement of lipoxygenase products in myometrial contractions. Prostaglandins, 26, 23–34 Huszar, G. (1981). Biology and biochemistry of myometrial contractility and cervical maturation.Semin. Perinatol, 3, 216–221 Garfield, R.E. and Hayashi, R.H. (1980). Presence of gap junctions in the myometrium of women during various stages of menstruation. Am. J. Obstet. Gynecol, 138, 569–574 Goldblatt, M.W. (1933). A depressor substance in seminal fluid. J. Soc. Chem. Ind., 52, 1056–1060 Von Euler, U.S. (1934). Zur kenntnis der pharmakologischen Wirkungen von nativsekreten und extrakten männlicher accessorischer geschlechtsdrüsen. Naunyn Schmiedeberg Arch. Pharm. Exp. Pathol, 175, 78–84 Karlson, S. (1959). The influence of seminal fluid on the motility of the non-pregnant human uterus. Acta Obstet. Gynecol Scand., 38, 503–511 Eliasson, R. and Posse, N. (1960). The effect of prostaglandin on the non-pregnant human uterus in vivo. Acta Obstet. Gynecol Scand., 39, 112–119 Roth-Brandel, U., Bygdeman, M. and Wiqvist, N. (1970). Effect of intravenous administration of prostaglandin E1 and F2α on the contractility of the non-pregnant human uterus in vivo. Acta Obstet. Gynecol Scand., 49, supplement 5, 19–25 Cibils, L.A. (1967). Contractility of the non-pregnant human uterus. Obstet. Gynecol, 30, 441–461 Borell, U., Bygdeman, M., Gréen, K. and Lundström, V. (1985). Physiology and pharmacology of prostacyclins and prostaglandins. In Shearman, R.P. (ed.) Clinical Reproductive Endocrinology, pp. 249–263. (Edinburgh: Churchill Livingstone) Clark, K.E., Farley, D.B., Van Orden, D.E. and Brodie, M.J. (1977). Role of endogenous prostaglandins in regulation of uterine blood flow and adrenergic neurotransmission. Am. J. Obstet. Gynecol, 127, 455–461 Short, R.V. (1976). The evolution of human reproduction. Proc. R. Soc. London, B195, 3–24 Hallberg, L., Hogdahl, A.M., Nilson, L. and Rybo, G. (1966). Menstrual blood loss-a population study. Acta. Obstet. Gynecol Scand., 45, 320–351 Fraser, I.S., McCarron, G., Markham, R. and Resta, T. Blood and total fluid content of menstrual discharge. Obstet. Gynecol, 65, 194–198 Flowers, C.E. and Willborn, W.H. (1978). New observations on the physiology of menstruation. Obstet. Gynecol, 51, 16–24 Markee, J.E. (1940). Menstruation in intraocular endometrial transplants in the rhesus monkey. Contrib. Embryol, (Carnegie Inst, of Washington),28, 219–308 Abel, M.H. (1985). Prostaglandins and leukotrienes in menstruation. Prostagl. Perspect., 1, 1–4 Henzl, M.R., Smith, R.C., Boost, G. and Tyler, E.T. (1972). Lysosomal concept of menstrual bleeding in humans. J. Clin. Endocrinol Metab., 34, 860–875 Wiqvist, N., Bygdeman, M. and Kirton, K. (1971). Non-steroidal infertility agents in the female. In Diczfalusy, E. and Borell, U. (eds.) Control of Human Fertility, Nobel Symposium, 15, 137–148 Smith, S.K., Abel, M.H., Kelly, R.W. and Baird, D.T. (1981). Prostaglandin synthesis in the endometrium of women with ovular dysfunctional uterine bleeding. Br. J. Obstet. Gynaecol, 88, 434–439 Paton, R.C., Tindali, H., Zuzel, M. and McNicol, G.P. (1980). Haemostatic mechanisms in the normal endometrium and endometrium exposed to contraceptive steroids. In Diczfalusy, E., Fraser, I.S. and Webb, F.T.G. (eds.) Endometrial Bleeding and Steroidal Contraception, pp. 325–341. (Bath: Pitman Press) Sixma, JJ., Christiaens, G.C.M.L. and Haspels, A.A. (1980). The sequence of haemostatic events in the endometrium during normal menstruation. In Diczfalusy, E, Fraser, I.S., Webb, F.T.G. (eds.) Endometrial Bleeding and Steroidal Contraception, pp. 86–96. (Bath: Pitman Press) Rybo, G. (1966). Plasminogen activator in the endometrium. Acta Obstet. Gynecol Scand., 45, 411–450 Christiaens, G.C.M.L., Sixma, J.J. and Haspels, A.A. (1980). Morphology of haemostasis in menstrual endometrium. Br. J. Obstet. Gynaecol, 87, 425–439 Baird, D.T., Abel, M.H., Kelly, R.W. and Smith, S.K. (1981). Endocrinology of dysfunctional uterine bleeding: the role of endometrial prostaglandins. In Crosignani, P.G. and Rubin, B. (eds.) Endocrinology of Human Infertility: New Aspects, pp. 399–417. Proceedings of the Serono clinical colloquia on reproduction 2, September 1980. (Oxford: Academic Press) Goodfellow, C.F., Paton, R.C., Salmon, J.A., Moncada, S., Clayton, J.K., Davies, J.A. and McNicol, G.P. (1982). 6-oxo-prostaglandin F1α and thromboxane B2 in uterine vein blood – a possible role in menstrual bleeding. Thromb. Haemostas., 48, 9–12 Fraser, I.S. (1982). Quoted by Turnbull, A.C. Aspects of dysfunctional uterine bleeding; summary and conclusion. Res. Clin. Forums, 4, 143 Fraser, I.S. (1985). The ‘dysfunctional’ uterus: dysmenorrhoea and dysfunctional uterine bleeding. In Shearman, R.P. (ed.) Clinical Reproductive Endocrinology, pp. 579–598 (Edinburgh: Churchill Livingstone) Carney, M.W. (1981). Menstrual disturbance: a psychogenic disorder? Clin. Obstet. Gynaecol, 8, 103–109 Åkerlund, M., Anderssen, K.-E., Ingermarsson, I. (1976). Effects of terbutaline on myometrial activity, uterine blood flow and lower abdominal pain in women with primary dysmenorrhoea. Br. J. Obstet. Gynaecol, 83, 673–681 Smith, R.P. and Powell, J.R. (1980). The objective evaluation of dysmenorrhoea therapy. Am. J. Obstet. Gynecol, 137, 314–319 Lumsden, M.A. and Baird, D.T. (1985). Intrauterine pressure in dysmenorrhoea.Acta Obstet. Gynecol Scand., 64, 183–186 Irwin, J., Morse, E. and Riddick, D. (1981). Dysmenorrhoea induced by autologous transfusion. Obstet. Gynecol, 58, 286–294 Ferreira, S.H. (1981). Inflammatory pain, prostaglandin hyperalgesia and the development of peripheral analgesic trends. Pharmacol Sci., 2, 183–186 Lundström, V. and Gréen, K. (1978). Endogenous levels of PGF2α and its main metabolites in plasma and endometrium of normal and dysmenorrhea women. Am. J. Obstet. Gynecol, 130, 640–649 Rosenwaks, Z., Jones, G.S., Henzl, M.R., Dubin, N.H., Ghodgoankar, R.B. and Hofmann, S. (1981). Naproxen sodium, aspirin and placebo in primary dysmenorrhoea. Am. J. Obstet. Gynecol, 140, 592–599 Lumsden, M.A., Kelly, R.W. and Baird, D.T. (1983). Is prostaglandin F2α involved in the increased myometrial contractility of primary dysmenorrhoea. Prostaglandins, 25, 683–691 Lundström, V. (1977). The myometxial response to intrauterine administration of PGF2α and PGE2in dysmenorrhoeic women. Acta Obstet. Gynecol. Scand., 56, 167–173 Demers, L.M., Hahn, D.W. and McGuire, J.L. (1984). Newer concepts in dysmenorrhoea research. In Dawood, M.Y., McGuire, J.L. and Demers, L.M. (eds.) Premenstrual Syndrome and Dysmenorrhoea, pp. 205–220. (Baltimore: Urban and Schwarzenburg) Ylikorkala, O., Puolakka, J. and Kauppila, A. (1979). Serum gonadotrophins, prolactin and ovarian steroids in primary dysmenorrhoea. Br. J. Obstet. Gynaecol, 86, 648–653 Stromberg, P., Forsling, M.L. and Akerlund, M. (1981). Effects of prostaglandin inhibition on vasopressin levels in women with primary dysmenorrhoea. Obstet. Gynecol, 58, 206–208 Sjoberg, N.-O. (1979). Dysmenorrhoea and uterine neurotransmitters. Acta. Obstet. Gynecol Scand., 87, (supplement) 57–60 Hillier, A. and Kasonde, J.M. (1976). Prostaglandin E and F concentrations in human endometrium after insertion of an intrauterine contraceptive device. Lancet, 1, 15–16 Janbu, T., Lokken, P. and Neshein, B.-I. (1979). Effect of acetyl salicyclic acid, paracetamol and placebo on pain and blood loss in dysmenorrhoeic woman.Acta Obstet. Gynecol Scand., 87, (supplement) 81–86 Kremser, E. and Mitchell, G.M. (1971). Treatment of primary dysmenorrhoea with a combined-type oral contraceptive: a double blind study. J. Am. Coll. Health Assoc., 19, 195–199 Schwarz, A., Zor, U., Lindner, H.R. and Naor, S. (1974). Primary dysmenorrhoea: alleviation by an inhibitor of prostaglandin synthesis and action. Obstet. Gynecol, 44, 709–714 Anderson, A.B.M., Fraser, I.S., Haynes, P J. and Turnbull, A.C. (1978). Trial of prostaglandin synthetase inhibitors in primary dysmenorrhoea.Lancet, 1, 345–348 Kintis, G.A. and Contifaris, B. (1980). The treatment of primary dysmenorrhoea with mefenamic acid. Int. J. Gynecol Obstet., 18, 172–175 Henzl, M.R., Ortega-Herrera, E., Rodriguez, C. and Izu, A. (1979). Anaprox in dysmenorrhoea; reduction of pain and intrauterine pressure.Am. J. Obstet. Gynecol, 135, 455–460 Henzl, M.R., Massey, S. and Hanson, F.W. (1980). Primary dysmenorrhoea: the therapeutic challenge. J. Reprod. Med., 25, (supplement) 226–234 Pulkkinen, M.O. and Csapo, A.I. (1978). Effect of ibuprofen on menstrual blood prostaglandin levels in dysmenorrhoeic women. Prostaglandins, 18, 137–142 Poyser, N.L. (1985). Prostaglandin pharmacology: five differential inhibitors of prostanoid synthesis. Prostagl. Perspect., 2, 10–11 Andersson, K.-E. and Ulmsten, U. (1978). Effects of nifedipine on myometrial activity and lower abdominal pain in patients with primary dysmenorrhoea.Br. J. Obstet. Gynaecol, 85, 142–149 Kauppila, A., Puolakka, J. and Ylikorkala, O. (1979). Prostaglandin biosynthesis inhibitors and endometriosis. Prostaglandins, 18, 655–661 Buttram, V., Izu, A. and Henzl, M.R. (1979). Naproxen sodium in uterine pain following intrauterine contraceptive device insertion. Am. J. Obstet. Gynecol, 134, 575–580 Cole, S.K., Billewicz, W.Z. and Thomson, A.M. (1971). Sources of variation in menstrual blood loss. J. Obstet. Gynaecol Br. Commonw., 78, 933–939 Brown, J.B., Kellar, R.J. and Matthew, G.D. (1959). Preliminary observations on urinary oestrogen excretion in certain gynaecological disorders. J. Obstet. Gynaecol Br. Emp., 66, 177–211 Sutherland, A.M. (1949). The Histology of the endometrium in functional uterine haemorrhage. Glasgow Med. J., 30, 1–28 Beilby, J.O.W., Farrer-Brown, G. and Tarbit, M.H. (1971). The microvasculature of common uterine abnormalities excluding fibroids.J. Obstet. Gynaecol Br. Commonw., 78, 361–368 Willman, E.A., Collins, W.P. and Clayton, S.G. (1976). Studies in the involvement of prostaglandins in uterine symptomatology and pathology. Br. J. Obstet. Gynaecol, 83, 337–345 Smith, S.K., Abel, M.H., Kelly, R.W. and Baird, D.T. (1982). The synthesis of prostaglandins from persistent proliferative endometrium. J. Clin. Endocrinol Metab., 55, 284–289 Smith, S.K., Abel, M.H., Kelly, R.W. and Baird, D.T. (1981). A role for prostacyclin (PGI2) in excessive menstrual bleeding. Lancet, 1, 522–524 Rees, M.C.P., Anderson, A.B.M., Demers, L.M. and Turnbull, A.C. (1984). Endometrial and myometrial prostaglandin release during the menstrual cycle in relation to menstrual blood loss. J. Clin. Endocrinol Metab., 58, 813–818 Hoffman, G.E., Rao, C.V., De Leon, F.D., Toledo, A.A. and San Filippo, J.S. (1985). Human endometrial prostaglandin E2 binding sites and their profiles during the menstrual cycle and in pathologic states. Am. J. Obstet. Gynecol, 151, 369–375 Anderson, A.B.M., Haynes, E.J., Guillebaud, J. and Turnbull, A.C. (1976). Reduction of menstrual blood loss by prostaglandin synthetase inhibitors. Lancet, 1, 774–776 Fraser, I.S., Pearse, C., Shearman, R.P., Elliott, P.M., McIlveen, J. and Markham, R. (1981). Efficacy of mefenamic acid in patients with a complaint of menorrhagia. Obstet. Gynecol, 58, 543–551 Fraser, I.S., McCarron, G., Markham, R., Robinson, M. and Smyth, E. (1983). Long term treatment of menorrhagia with mefenamic acid. Obstet. Gynecol, 61, 109–112 Fraser, I.S. (1983). The treatment of menorrhagia with mefenamic acid. Res. Clin. Forums, 5, No. 3, 93–99 Guillebaud, J., Anderson, A.B.M. and Turnbull, A.C. (1978). Reduction by mefenamic acid of increased menstrual blood loss associated with intrauterine contraception.Br.J. Obstet. Gynaecol, 85, 53–62 Fraser, I.S., McCarron, G., Markham, R., Resta, T. and Watts, A. (1986). Measured menstrual blood loss in women with menorrhagia associated with pelvic disease or coagulation disorder. Obstet. Gynecol, (in press) Damarawy, H. and Toppozada, M. (1976). Control of bleeding due to I.U.D’ s by a prostaglandin biosynthesis inhibitor.IRCS Med. Sci., Reprod., Obstet. Gynecol, 4, 5–7 Davies, A.J., Anderson, A.B.M. and Turnbull, A.C. (1981). Reduction by Naproxen of excessive menstrual bleeding in women using intrauterine devices. Obstet. Gynecol, 57, 74–78 Harrison, R.F. and Campbell, S. (1976). Double-blind trial of Ethamsylate in the treatment of primary and intrauterine device menorrhagia. Lancet, 2, 283–285 Kovacs, L. and Annus, J. (1978). Effectiveness of Ethamsylate in intrauterine device menorrhagia. Gynecol Invest., 9, 161–165 Reid, R. (1985). Premenstrual syndrome. Curr. Probl Obstet, and Gynecol, 8, No. 2, 1–57 Craig, G. (1980). The premenstrual syndrome and prostaglandin metabolism. Br. J. Fam.Plann., 6, 74–77 Jakubowicz, D.L. (1983). The significance of prostaglandins in the premenstrual syndrome. Res. Clin Forums, 5, No. 3, 59–66 Poddubiuk, Z. (1976). A comparison of the central actions of prostaglandins A1 E1 Flα and F2α in the rat. 1. Behavioural, antinocioceptive and anticonvulsant actions of intraventricular prostaglandins in the rat. Psychol Pharmacol, 50, 89–94 Baile, C.A. and Martin, F.H. (1973). Relationship between prostaglandin E1 polyphloretin phosphate and β-adrenoreceptor bound feeding loci in the hypothalamus of sheep. Pharmacol Biochem. Behav., 1 , 530–545 Juan, H. (1978). Prostaglandins as modulators of pain.Gen. Pharmacol, 9, 403–409 Wood, C. and Jakubowicz, D.L. (1980). The treatment of premenstrual symptoms with mefenamic acid. Br. J. Obstet. Gynaecol, 87, 627–630 Jakubowicz, D.L., Wood, C. and Dewhurst, C.J. (1982). The treatment of premenstrual tension. Res. Clin. Forums, 4, 119–124 Mira, M., McNeil, D., Fraser, I.S., Vizzard, J. and Abraham, S. (1986). The use of mefenamic acid in the treatment of premenstrual tension sufferers. Obstet. Gynecol, 68, 395–398 Brush, M.G. (1981). Efamol in the treatment of premenstrual syndrome. Proceedings of the 1st symposium on the clinical uses of Efamol and essential fatty acids. St Thomas’ Hospital, London Moon, Y.S., Leung, T.C.S., Yuen, B.H. and Gomel, V. (1981). Prostaglandin F. in human endometriotic tissue. Am. J. Obstet. Gynecol, 141, 344–345 Drake, T.S., O’Brien, W.F., Ramwell, P.W. and Metz, S.A. (1981). Peritoneal fluid thromboxane B2 and 6-keto PGFlα in endometriosis. Am. J. Obstet. Gynecol, 140, 401–406 Mudge, T.J., James, M.J., Jones, W.R. and Walsh, J.A. (1985). Peritoneal fluid 6-keto PGFlα levels in women with endometriosis. Am. J. Obstet. Gynecol, 152, 901–904 Rock, J.A., Dubin, N.H., Ghodgaonkar, R.B., Bergquist, C.A., Erozan, Y.S. and Kimball, A.W. (1982). Cul-de-sac fluid in women with endometriosis: fluid volume and prostanoid concentration during the proliferative phase of the cycle. Fertil Steril, 37, 747–758 Carlson, L.A., Ekelund, L.G. and Oro, L. (1968). Clinical and metabolic effects of prostaglandin E1 in man. Acta Med. Scand., 183, 423–430 Peatfield, R.C., Gawell, M.J. and Clifford-Rose, F. (1981). The effect of infused prostacyclin in migraine and cluster headache. Headache, 21, 190–195 Horrobin, D.F. (1977). Hypothesis: prostaglandins and migraine. Headache, 17, 113–117 Editor information Editors and Affiliations Rights and permissions Copyright information © 1987 MTP Press Limited About this chapter Cite this chapter Fraser, I.S. (1987). Eicosanoids, menstruation and menstrual disorders. In: Hillier, K. (eds) Eicosanoids and Reproduction. Advance in Eicosanoid Research, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3215-9_2 Download citation DOI: https://doi.org/10.1007/978-94-009-3215-9_2 Publisher Name: Springer, Dordrecht Print ISBN: 978-94-010-7943-3 Online ISBN: 978-94-009-3215-9 eBook Packages: Springer Book Archive

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