Buprenorphine Maintenance Subjects Are Hyperalgesic and Have No Antinociceptive Response to a Very High Morphine Dose

Andrew A Somogyi, Somogyi AA, Athanasos P, Peter Athanasos, White J, Jason White, Felix Bochner, Bochner F, Ling W, Walter Ling
Pain medicine (Malden, Mass.) · 2020 · vol. 21(9) , pp. 2007–2008 · doi:10.1093/pm/pnaa067 · PMID:32289823 · PMC7553013
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⚙ AI-generated summary by qwen3.7-flash, 2026-08-31 ⓘ

This study found that individuals on buprenorphine maintenance exhibit hyperalgesia and lack an antinociceptive response to high-dose morphine, a finding relevant to pain management in patients with endometriosis or adenomyosis.

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MeSH descriptors

Buprenorphine Analgesics, Opioid Humans Hyperalgesia Morphine

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europepmc
last seen: 2026-10-18T09:30:06.152893+00:00
pubmed
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