Distant recurrence of endometrial cancer more than 10 years after hysterectomy: a case report

Boom Ping Khoo, Kah Teik Chew, Erica Yee Hing, Nirmala Chandralega Kampan, Nirmala Kampan, Mohamad Nasir Shafiee
Hormone molecular biology and clinical investigation · 2021 · vol. 42(4) , pp. 429–433 · doi:10.1515/hmbci-2021-0025 · PMID:34378876 · W3190714587
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This case report and literature review describe a patient with distant endometrial cancer recurrence 23 years after hysterectomy, analyzing eleven similar cases to hypothesize that cell dormancy drives such late recurrences.

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Abstract

OBJECTIVES: Endometrial cancer is the sixth most common cancer among women and recurrence of after 10 years is extremely rare. CASE PRESENTATION: We reported a comprehensive review of histopathology, investigations and treatment regarding a woman with distant recurrence of endometrial cancer to rectus abdominis muscle after 23 years from the primary surgery. Previous published literatures of similar case were included into the review analysis. A total of 11 similar cases had been reported. Overall, 9 (81.8%) cases were stage 1 disease and only 2 cases were classified as stage II disease. The majority, 6 (54.5%) cases were endometrial adenocarcinoma. Majority of the cases shared the similarity of low grade endometrial cancer with positive oestrogen receptor immunophynetype. CONCLUSIONS: Thus, the phenomenon of 'cell dormancy' was hypothesized to explain the mechanism of late recurrence for these cases.

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MeSH descriptors

Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Female Humans Hysterectomy Recurrence Time Factors

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openalex
last seen: 2026-06-04T00:00:01.174412+00:00
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last seen: 2026-10-08T21:32:03.440833+00:00
License: CC0 · commercial use OK