The rat as an animal model for endometriosis to examine recurrence of ectopic endometrial tissue after regression

K. Rajkumar, Rajkumar K, P W Schott, Schott PW, C W Simpson, Simpson CW
Fertility and sterility · 1990 · vol. 53(5) , pp. 921–5 · doi:10.1016/s0015-0282(16)53532-8 · PMID:2332064
Lab / animal OA: closed public-domain-us
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This study demonstrates that ectopic endometrial cells survive apparent regression in a rat endometriosis model and can recur following estrogen administration or postpartum periods.

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Abstract

The effects of pregnancy and ovariectomy on the growth of endometrial implants were examined in rats with experimentally induced endometriosis. Ectopic implants regressed completely after ovariectomy and we were unable to detect any viable endometrial cells in histological examination of the implant sites. Administration of 17 beta-estradiol cypionate to ovariectomized rats with regressed endometrial implants led to recurrence of the regressed implants. Animals with experimentally induced endometriosis were fertile and the number of embryos on day 10 of pregnancy was not different from the control group. Ectopic implants which regressed during pregnancy recurred 1 month after parturition. It is concluded that endometrial cells may survive at the implanted site even after apparent complete morphological regression, which has the potential to grow into an implant.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Neoplasm Recurrence, Local Neoplasm Recurrence, Local Animals Animals Disease Models, Animal Disease Models, Animal Endometriosis Endometriosis Endometrium Endometrium Endometrium Estrogens Estrogens Estrogens Female Female Ovariectomy Ovariectomy Postpartum Period

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europepmc
last seen: 2026-10-24T06:12:55.650802+00:00
pubmed
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