The role of antioxidants in the complex therapy of patients with endometriosis-associated infertility

M.G. Khatlamadzhiyan, Е. В. Харитонова, L. N. Shcherbakova, Е. И. Каленикова, Medvedev Os, M.V. Alekseenkova, О.Б. Панина
In: Voprosy ginekologii, akušerstva i perinatologii · 2020 · vol. 19(6) , pp. 28–33 · doi:10.20953/1726-1678-2020-6-28-33 · W3134683211
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This study found that antioxidant therapy with ubidecarenone improved intrauterine perfusion in infertile patients with endometriosis after surgical treatment.

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This study evaluated the role of antioxidant therapy—using ubidecarenone (coenzyme Q10) provided via Synergin®—in 43 patients with endometriosis-associated infertility after laparoscopy, compared with 19 fertile control women with normal reproductive function. Endometrial receptivity and intrauterine perfusion (subendometrial and endometrial blood flow) were assessed before and after 3 months of therapy, with the aim of correcting antioxidant status and endothelial dysfunction. In the endometriosis-associated infertility group, intrauterine perfusion was significantly reduced at baseline, but after therapy subendometrial blood flow shifted to mostly satisfactory levels (from 13% satisfactory pre-therapy to 86% post-therapy), with a less pronounced change for endometrial blood flow (32% satisfactory pre-therapy to 45% post-therapy). The paper concludes that pathogenetic antioxidant therapy is necessary as part of complex infertility treatment in patients with external genital endometriosis after surgery. This paper is centrally about endometriosis — it specifically studies antioxidant therapy (ubidecarenone/coenzyme Q10) for endometriosis-associated infertility, focusing on endometrial receptivity and intrauterine perfusion.

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Abstract

Objective. To study the role of antioxidants in the complex therapy of patients with endometriosis-associated infertility on the example of evaluating the effectiveness of ubidecarenone. Patients and methods. Forty-three patients with endometriosis-associated infertility and nineteen fertile women with complete reproductive function were examined. In order to improve the receptivity of endometrium and correct the antioxidant status in infertile patients with endometriosis after laparoscopy, therapy with Synergin® was administered at a dosage of 2 capsules per day for 3 months. After therapy, an assessment of endometrium and intrauterine perfusion was made. Results. There was a significant decrease in intrauterine perfusion in patients with endometriosis-associated infertility compared to the control group. However, after therapy with Synergin® within 3 months and correction of endothelial dysfunction in infertile patients with endometriosis, an improvement in intrauterine perfusion was revealed. Thus, prior to therapy, subendometrial blood flow was assessed in 13% of patients as satisfactory, in 77% – it was reduced, in 10% – it was absent; after therapy, 86% of patients showed satisfactory blood flow and 14% had decreased blood flow. Endometrial blood flow was reduced in 32% of patients and in 68% were absent prior to treatment, and after treatment, it was assessed as satisfactory in 45% and was reduced in 55%. Conclusion. Pathogenetic antioxidant therapy is necessary in the complex therapy of infertility in patients with external genital endometriosis after surgical treatment. Key words: α-Tocopherol, infertility, coenzyme Q10, endometrium receptivity, endometriosis
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The role of antioxidants in the complex therapy of patients with endometriosis-associated infertility Meline G. Khatlamadzhiyan / Ekaterina V. Kharitonova / Liya N. Shcherbakova / Elena I. Kalenikova / Oleg S. Medvedev / Maria V. Alekseyenkova / Olga B. Panina / Objective. To study the role of antioxidants in the complex therapy of patients with endometriosis-associated infertility on the example of evaluating the effectiveness of ubidecarenone. Patients and methods. Forty-three patients with endometriosis-associated infertility and nineteen fertile women with complete reproductive function were examined. In order to improve the receptivity of endometrium and correct the antioxidant status in infertile patients with endometriosis after laparoscopy, therapy with Synergin® was administered at a dosage of 2 capsules per day for 3 months. After therapy, an assessment of endometrium and intrauterine perfusion was made. Results. There was a significant decrease in intrauterine perfusion in patients with endometriosis-associated infertility compared to the control group. However, after therapy with Synergin® within 3 months and correction of endothelial dysfunction in infertile patients with endometriosis, an improvement in intrauterine perfusion was revealed. Thus, prior to therapy, subendometrial blood flow was assessed in 13% of patients as satisfactory, in 77% – it was reduced, in 10% – it was absent; after therapy, 86% of patients showed satisfactory blood flow and 14% had decreased blood flow. Endometrial blood flow was reduced in 32% of patients and in 68% were absent prior to treatment, and after treatment, it was assessed as satisfactory in 45% and was reduced in 55%. Conclusion. Pathogenetic antioxidant therapy is necessary in the complex therapy of infertility in patients with external genital endometriosis after surgical treatment. Key words: α-Tocopherol, infertility, coenzyme Q10, endometrium receptivity, endometriosis For citation: Khatlamadzhiyan M.G., Kharitonova E.V., Shcherbakova L.N., Kalenikova E.I., Medvedev O.S., Alekseenkova M.V., Panina O.B. The role of antioxidants in the complex therapy of patients with endometriosis-associated infertility. Vopr. ginekol. akus. perinatol. (Gynecology, Obstetrics and Perinatology). 2020; 19(6): 28–33. (In Russian). DOI: 10.20953/1726-1678-2020-6-28-33 Open access

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