Uterine Adenosarcoma Originating in Adenomyosis: Report of an Extremely Rare Phenomenon and Review of Published Literature

Karen L Talia, Yael Naaman, W Glenn McCluggage
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists · 2020 · vol. 40(4) , pp. 342–348 · doi:10.1097/pgp.0000000000000709 · PMID:32947330 · W3087473809
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This report describes an extremely rare case of intramural uterine adenosarcoma arising in adenomyosis without surface endometrial involvement and reviews eight similar cases.

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Abstract

Müllerian adenosarcoma is an uncommon biphasic malignant tumor most often occurring in the uterine corpus and derived from native surface endometrium. We report a case of intramural uterine adenosarcoma arising in association with adenomyosis, in the absence of tumor involving the surface endometrium. This is an extremely rare phenomenon, with only 8 other published cases of uterine corpus adenosarcoma in the absence of surface endometrial involvement, 5 originating in adenomyosis and 3 in adenomyomas. We review these cases. The current FIGO staging system for uterine adenosarcoma assumes origin from the surface endometrium and does not address the rare occurrence of intramural tumors without a surface endometrial component. Such tumors are problematic to stage and could potentially be overtreated, particularly if there is deep myometrial involvement.

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Condition tags

adenomyosis

MeSH descriptors

Adenomyoma Adenomyosis Adenosarcoma Uterine Neoplasms Adenomyoma Adenomyoma Adenomyosis Adenomyosis Adenosarcoma Adenosarcoma Adenosarcoma Adenosarcoma Adult Female Humans Hysterectomy Myometrium Myometrium Uterine Neoplasms Uterine Neoplasms

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (25)

Cited by (5)

Source provenance

europepmc
last seen: 2026-06-04T01:30:01.192114+00:00
openalex
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pubmed
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